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PRPF40B Knockout Cell Lines

Gene: PRPF40B

Official Full Name: pre-mRNA processing factor 40 homolog Bprovided by HGNC

Gene Summary: This gene encodes a WW-domain containing protein similar to yeast splicing factor PRP40. This protein has been shown to interact with Huntingtin and methyl CpG binding protein 2 (MeCP2). Alternative splicing results in different transcript variants. [provided by RefSeq, Aug 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00468 PRPF40B gRNA1-gRNA2 KO plasmid PRPF40B $850
KO00404 PRPF40B Knockout cell line (HeLa) Human PRPF40B 1:3~1:6 Negative Online Inquiry
KO14869 PRPF40B Knockout cell line (HCT 116) Human PRPF40B 1:2~1:4 Negative Online Inquiry
KO14870 PRPF40B Knockout cell line (HEK293) Human PRPF40B 1:3~1:6 Negative Online Inquiry
KO14871 PRPF40B Knockout cell line (A549) Human PRPF40B 1:3~1:4 Negative Online Inquiry

Background

PRPF40B Gene Knockout Cell Lines are genetically engineered cell lines designed specifically to study the function of the PRPF40B gene in cellular processes. This gene is known to play critical roles in RNA splicing and gene expression regulation, making it a pivotal component for understanding various biological mechanisms and their implications in diseases. By creating knockout models, researchers can effectively investigate the loss-of-function effects of PRPF40B, providing insights into its role in cellular mechanisms, particularly in the context of cancer and other genetic disorders.

The key function of PRPF40B Gene Knockout Cell Lines lies in their ability to serve as a reliable platform for investigating the biological pathways influenced by the PRPF40B gene. Through CRISPR-Cas9 technology or other gene-editing techniques, the PRPF40B gene is rendered inactive, allowing researchers to closely examine phenotypic changes and alterations in gene expression profiles that occur as a result of this genetic modification. This mechanism facilitates an in-depth understanding of how PRPF40B contributes to the spliceosomal machinery and its broader implications in health and disease.

The scientific importance of these knockout cell lines cannot be overstated. In research, they provide invaluable resources for studying splicing disorders and developing targeted therapies, especially for malignancies where aberrations in RNA processing are prevalent. Clinically, these models hold potential for evaluating drug responses, characterizing tumor biology, and advancing personalized medicine approaches.

Compared to alternative models, PRPF40B Gene Knockout Cell Lines offer distinct advantages, including high specificity and sensitivity in elucidating the effects of targeted gene disruption. They also foster reproducibility in experimental designs, thanks to their precise genetic background. These features position them as superior tools in both fundamental research and translational applications.

For researchers and clinicians seeking to advance their understanding of the PRPF40B gene and its implications in health, these knockout cell lines represent a strategic investment in developing innovative therapeutic strategies. Our company specializes in the development and provision of cutting-edge biological products, ensuring the highest quality standards and support for your research endeavors. With extensive expertise in molecular biology and genetics, we are dedicated to equipping the scientific community with tools that drive discovery and foster advancements in biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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