Gene: PROCR
Official Full Name: protein C receptorprovided by HGNC
Gene Summary: The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31735 | PROCR Knockout cell line (HeLa) | Human | PROCR | 1:3~1:6 | Negative | Online Inquiry |
KO31736 | PROCR Knockout cell line (HCT 116) | Human | PROCR | 1:2~1:4 | Negative | Online Inquiry |
KO31737 | PROCR Knockout cell line (HEK293) | Human | PROCR | 1:3~1:6 | Negative | Online Inquiry |
KO31738 | PROCR Knockout cell line (A549) | Human | PROCR | 1:3~1:4 | Negative | Online Inquiry |
PROCR Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of the protein C receptor (PROCR) and its implications in various biological processes, including coagulation, inflammation, and cellular signaling pathways. These cell lines have been engineered through precise gene editing techniques to disrupt the PROCR gene, effectively creating a knockdown effect that allows researchers to analyze the absence of PROCR's influence on cell behavior and phenotype.
The primary function of PROCR Gene Knockout Cell Lines is to serve as an essential tool in elucidating the role of PROCR in health and disease. By utilizing advanced CRISPR-Cas9 technology, the knockout lines enable scientists to systematically examine the downstream effects of PROCR deficiency, including alterations in signaling pathways and changes in cellular responses to stimuli. This mechanistic insight is invaluable for understanding how disruptions in PROCR function may contribute to disease states such as thrombosis, sepsis, and cancer.
The scientific significance of these knockout cell lines extends across multiple research fields, including pharmacology, toxicology, and personalized medicine. They are particularly useful in drug development, where assessing the interaction between therapeutic agents and the coagulation cascade can lead to novel anti-coagulant therapies. Furthermore, they can be employed in genetic studies to unveil the receptor's role in macrophage activation and immune responses.
What sets PROCR Gene Knockout Cell Lines apart from conventional alternatives is their specificity and reliability. Unlike general knockout models that may exhibit off-target effects or unintended genetic background noise, these optimized lines provide a clean slate for researchers to investigate PROCR's specific functions with high reproducibility.
For researchers and clinicians alike, the value of PROCR Gene Knockout Cell Lines lies in their ability to enhance understanding of PROCR's biological contributions and improve the translational potential of novel therapies targeting pathways influenced by PROCR. As a leader in the field of biological research products, our company is dedicated to providing high-quality cellular models that support cutting-edge scientific exploration and innovation. By equipping researchers with reliable tools like these knockout cell lines, we empower advancements in both basic and applied science.
Please note that all services are for research use only. Not intended for any clinical use.
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