Gene: PRMT9
Official Full Name: protein arginine methyltransferase 9provided by HGNC
Gene Summary: This gene encodes a type II methyltransferase. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to the guanidino nitrogen atoms of arginine. The protein encoded by this gene methylates spliceosome associated protein 145 to regulate alternative splicing and acts as a modulator of small nuclear ribonucleoprotein maturation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23635 | PRMT9 Knockout cell line (HeLa) | Human | PRMT9 | 1:3~1:6 | Negative | Online Inquiry |
KO23636 | PRMT9 Knockout cell line (HCT 116) | Human | PRMT9 | 1:2~1:4 | Negative | Online Inquiry |
KO23637 | PRMT9 Knockout cell line (HEK293) | Human | PRMT9 | 1:3~1:6 | Negative | Online Inquiry |
KO23638 | PRMT9 Knockout cell line (A549) | Human | PRMT9 | 1:3~1:4 | Negative | Online Inquiry |
PRMT9 Gene Knockout Cell Lines are highly specialized cellular models designed to facilitate the study of protein arginine methylation and its implications in various biological processes. PRMT9, a member of the protein arginine methyltransferase family, plays a crucial role in gene expression regulation, RNA processing, and chromatin remodeling. By utilizing these knockout cell lines, researchers can effectively investigate the loss-of-function effects associated with PRMT9, providing insights into its contributions to cellular signaling pathways and disease mechanisms.
The PRMT9 Gene Knockout Cell Lines operate by employing CRISPR-Cas9 technology to specifically target and delete the PRMT9 gene. This precise editing leads to a lack of PRMT9 expression, enabling scientists to directly observe alterations in methylation patterns and cellular behaviors. Researchers can utilize these cell lines to elucidate the role of PRMT9 in various contexts, including cancer biology, neurobiology, and developmental studies, making them valuable tools in both experimental and clinical research.
The scientific importance of PRMT9 manipulation lies in its potential to reveal the underlying molecular pathways affected by this enzyme, ultimately informing therapeutic strategies for diseases linked to dysregulated arginine methylation. Compared to traditional knockdown methods, our knockout cell lines offer a complete ablation of PRMT9 function, providing a clearer picture of the gene's role and eliminating the partial or transient effects seen with RNA interference techniques.
Our PRMT9 Gene Knockout Cell Lines stand out in the marketplace due to their high efficiency, reproducibility, and ease of use, offering thaw-and-use convenience for laboratories aiming to streamline their projects. This product is particularly valuable to researchers and clinicians looking to advance their understanding of PRMT9's biological functions, thereby paving the way for novel therapeutic interventions.
As a leader in the development of innovative cellular products, our company is committed to supporting scientific progress by providing high-quality research tools that enhance experimental accuracy and expand the possibilities of discovery in molecular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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