Gene: PRMT3
Official Full Name: protein arginine methyltransferase 3provided by HGNC
Gene Summary: This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09364 | PRMT3 Knockout cell line (HeLa) | Human | PRMT3 | 1:3~1:6 | Negative | Online Inquiry |
KO09365 | PRMT3 Knockout cell line (HCT 116) | Human | PRMT3 | 1:2~1:4 | Negative | Online Inquiry |
KO09366 | PRMT3 Knockout cell line (HEK293) | Human | PRMT3 | 1:3~1:6 | Negative | Online Inquiry |
KO09367 | PRMT3 Knockout cell line (A549) | Human | PRMT3 | 1:3~1:4 | Negative | Online Inquiry |
PRMT3 Gene Knockout Cell Lines are genetically engineered cellular models designed to investigate the functional implications of the PRMT3 gene in various biological contexts. These cell lines are pivotal in the study of protein arginine methylation—a post-translational modification regulated by protein arginine methyltransferases (PRMTs), including PRMT3. By eliminating the expression of the PRMT3 gene, researchers can elucidate the role of this enzyme in cellular processes such as gene expression regulation, RNA processing, and signal transduction.
The key function of PRMT3 is its involvement in the methylation of histones and non-histone proteins, influencing chromatin structure and modulating transcription. This gene product plays a significant role in essential cellular functions, including proliferation, differentiation, and cellular responses to stress. The PRMT3 Gene Knockout Cell Lines serve as powerful tools for dissecting the mechanistic pathways impacted by the absence of this enzyme, which could unveil novel therapeutic targets for diseases associated with dysregulated arginine methylation, such as cancer and neurodegeneration.
In scientific research and clinical settings, these cell lines provide unique insights into the pathological roles of PRMT3 and allows investigators to develop targeted interventions. Unlike traditional methods that may rely on transient knockdown techniques, these stable knockout cell lines ensure lasting suppression of PRMT3, offering reproducibility and reliability in experimental outcomes.
Moreover, researchers benefit from using PRMT3 Gene Knockout Cell Lines as they provide a streamlined approach to explore complex biological systems, making them indispensable for studies focused on epigenetics and metabolic disorders. The implications of this research can lead to enhanced understanding and potential advancements in therapeutic strategies.
We pride ourselves on our commitment to delivering high-quality biological products tailored for cutting-edge research. With a portfolio that emphasizes genetic innovation, our expertise in developing and validating knockout cell lines ensures that you receive reliable tools to support your scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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