Gene: PRKRIP1
Official Full Name: PRKR interacting protein 1provided by HGNC
Gene Summary: Predicted to enable double-stranded RNA binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Involved in renal system process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14886 | PRKRIP1 Knockout cell line (HeLa) | Human | PRKRIP1 | 1:3~1:6 | Negative | Online Inquiry |
KO14887 | PRKRIP1 Knockout cell line (HCT 116) | Human | PRKRIP1 | 1:2~1:4 | Negative | Online Inquiry |
KO14888 | PRKRIP1 Knockout cell line (HEK293) | Human | PRKRIP1 | 1:3~1:6 | Negative | Online Inquiry |
KO14889 | PRKRIP1 Knockout cell line (A549) | Human | PRKRIP1 | 1:3~1:4 | Negative | Online Inquiry |
PRKRIP1 Gene Knockout Cell Lines are engineered cellular models that specifically lack the expression of the PRKRIP1 gene, which encodes the Protein Kinase Regulator Interacting Protein 1. These cell lines serve as a vital tool for investigating the biological role of PRKRIP1 in cellular processes such as stress response, apoptosis, and immune regulation. The knockout of this gene facilitates the study of its functional implications in various signaling pathways, thereby enabling researchers to elucidate its contribution to cellular homeostasis and disease mechanisms.
The principal mechanism underpinning these cell lines involves the utilization of CRISPR-Cas9 technology for precise gene editing, allowing the ablation of PRKRIP1. This technique provides a robust means to create genetically modified cells that serve as a platform for functional assays and molecular analyses. Researchers can evaluate the resultant phenotypic changes, assess gene interaction networks, and identify potential compensatory mechanisms that may arise from the loss of PRKRIP1.
Scientific studies utilizing PRKRIP1 knockout cell lines have applications in cancer research, neurobiology, and immunotherapy, where understanding the regulation of cellular stress responses is crucial. By investigating these models, scientists can gain insights into therapeutic vulnerabilities, novel drug targets, or biomarkers for disease prognosis.
One of the distinct advantages of our PRKRIP1 Gene Knockout Cell Lines is the high efficiency of gene disruption achieved through our optimized CRISPR protocols, ensuring minimal off-target effects and high reproducibility. Unlike conventional knockout methods, our cell lines provide a more reliable and manageable platform for high-throughput screenings and functional assays, thus expediting the research process.
For researchers and clinicians seeking deep insights into gene function and pathways, these knockout cell lines present an unmatched value, driving investigations that might lead to groundbreaking discoveries or therapeutic developments. Our company specializes in high-quality biological products that are rigorously validated and backed by our extensive expertise in genetic engineering and cell biology, ensuring researchers have access to the best tools for their work.
Please note that all services are for research use only. Not intended for any clinical use.
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