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PRKD3 Knockout Cell Lines

Gene: PRKD3

Official Full Name: protein kinase D3provided by HGNC

Gene Summary: This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08763 PRKD3 Knockout cell line (HeLa) Human PRKD3 1:3~1:6 Negative Online Inquiry
KO08764 PRKD3 Knockout cell line (HCT 116) Human PRKD3 1:2~1:4 Negative Online Inquiry
KO08765 PRKD3 Knockout cell line (HEK293) Human PRKD3 1:3~1:6 Negative Online Inquiry
KO08766 PRKD3 Knockout cell line (A549) Human PRKD3 1:3~1:4 Negative Online Inquiry

Background

PRKD3 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of the PRKD3 gene, which encodes protein kinase D3—a crucial player in a myriad of cellular processes, including proliferation, differentiation, and apoptosis. These cell lines have undergone targeted gene editing techniques to create a loss-of-function model that researchers can utilize to dissect the biological roles of PRKD3 in various physiological and pathological contexts.

The key mechanism through which these knockout cell lines operate involves the complete disruption of PRKD3 expression, leading to alterations in downstream signaling pathways. By eliminating the PRKD3 gene, researchers can observe the resultant phenotypes, thereby elucidating its role in cancer biology, cardiovascular diseases, and neurodegenerative disorders. This functional analysis is imperative for understanding cellular responses to stimuli and therapeutic interventions.

The scientific importance of PRKD3 Gene Knockout Cell Lines extends to both basic and applied research. They serve as invaluable tools in drug discovery, allowing scientists to screen for therapeutic compounds targeting PRKD3-related pathways. Furthermore, in preclinical settings, these models enable the investigation of gene function in disease states, thus contributing to the development of novel therapeutic strategies.

What sets PRKD3 Gene Knockout Cell Lines apart from traditional models is their high specificity and reproducibility, minimizing off-target effects commonly associated with earlier gene editing approaches. These lines are rigorously validated, ensuring precise and consistent results across experiments. Furthermore, our commitment to providing comprehensive user support and detailed protocols enhances the overall experience, allowing researchers to minimize time spent on troubleshooting.

For researchers and clinicians aiming to unravel the complexities of cellular signaling and disease mechanisms, PRKD3 Gene Knockout Cell Lines represent an essential resource. By leveraging our extensive expertise in biological product development and genetic engineering, we offer high-quality, reproducible models that empower scientific discovery and innovation in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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