Gene: PRKAR2B
Official Full Name: protein kinase cAMP-dependent type II regulatory subunit betaprovided by HGNC
Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35922 | PRKAR2B Knockout cell line (HCT 116) | Human | PRKAR2B | 1:2~1:4 | Negative | Online Inquiry |
KO35923 | PRKAR2B Knockout cell line (HEK293) | Human | PRKAR2B | 1:3~1:6 | Negative | Online Inquiry |
KO35924 | PRKAR2B Knockout cell line (A549) | Human | PRKAR2B | 1:3~1:4 | Negative | Online Inquiry |
PRKAR2B Gene Knockout Cell Lines are genetically engineered cell lines characterized by the targeted deletion of the PRKAR2B gene, which encodes a regulatory subunit of protein kinase A (PKA). This innovative product is pivotal for studying the role of PKA in various cellular pathways, particularly those associated with signal transduction, metabolism, and cellular growth. The knockout of PRKAR2B leads to altered PKA signaling, providing researchers an essential tool for dissecting the complex mechanisms of cell regulation and how dysregulation may contribute to pathological conditions such as cancer and cardiovascular diseases.
The key function of PRKAR2B Gene Knockout Cell Lines lies in their ability to mimic disease states. By utilizing CRISPR/Cas9 technology, these cell lines provide a robust model to investigate the mechanistic underpinnings of signaling pathways that are mediated by PKA. Researchers can observe changes in cell proliferation, differentiation, and apoptosis when the PKA signaling is perturbed, thus offering insights into therapeutic interventions. Furthermore, these cell lines enable high-throughput screening of potential drug candidates that target specific pathways influenced by PRKAR2B.
The scientific importance of PRKAR2B Gene Knockout Cell Lines extends to both fundamental and translational research. In academic settings, they facilitate the understanding of molecular biology principles and cellular behavior, while in clinical applications, they are instrumental in identifying biomarkers and potential drug targets for diverse diseases.
Compared to traditional cell lines, the PRKAR2B Gene Knockout Cell Lines offer the distinct advantage of providing a more authentic representation of PKA-related phenotypes. This specificity enhances the reproducibility and reliability of experimental outcomes, making these cell lines a superior choice for researchers seeking precise results.
For researchers and clinicians focused on advancements in cellular biology and pharmacology, the value of PRKAR2B Gene Knockout Cell Lines is undeniable. They present a significant opportunity to yield groundbreaking discoveries that could reshape therapeutic approaches and improve patient outcomes.
Our company prides itself on providing high-quality, precision-researched biological products, and the PRKAR2B Gene Knockout Cell Lines are a testament to our commitment to facilitating cutting-edge scientific research and development in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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