Gene: PREX1
Official Full Name: phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1provided by HGNC
Gene Summary: The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO14891 | PREX1 Knockout cell line (HeLa) | Human | PREX1 | 1:3~1:6 | Negative | Online Inquiry |
KO14892 | PREX1 Knockout cell line (HCT 116) | Human | PREX1 | 1:2~1:4 | Negative | Online Inquiry |
KO14893 | PREX1 Knockout cell line (HEK293) | Human | PREX1 | 1:3~1:6 | Negative | Online Inquiry |
KO14894 | PREX1 Knockout cell line (A549) | Human | PREX1 | 1:3~1:4 | Negative | Online Inquiry |
PREX1 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to study the functional role of the PREX1 gene, which is involved in diverse cellular processes including cellular signaling, migration, and invasion. These knockout cell lines offer a critical tool for probing the molecular mechanisms underlying various diseases, particularly cancer, where dysregulation of the PREX1 pathway has been implicated.
The core functionality of PREX1 Gene Knockout Cell Lines lies in their capacity to completely eliminate the expression of the PREX1 gene through CRISPR/Cas9 technology. This precision gene-editing technique ensures that the resultant cell lines exhibit a specific and stable knockout, enabling researchers to investigate the phenotypic and molecular consequences of PREX1 depletion. The use of these cell lines allows for in-depth studies on cell behavior, drug response, and resistance mechanisms, thereby facilitating the identification of novel therapeutic targets.
Scientifically, these knockout cell lines are of paramount importance in both research and clinical settings. They provide a robust platform for elucidating the role of PREX1 in tumor progression and metastasis, thereby advancing our understanding of oncogenic signaling pathways. In translational research, the insights gleaned from these models can contribute significantly to the development of new diagnostic biomarkers and therapeutic strategies for cancer treatment.
Compared to other alternatives, PREX1 Gene Knockout Cell Lines offer several unique advantages: they are engineered for specificity, allowing for targeted studies without the confounding effects of alternative pathways; their high reproducibility ensures consistency across experiments; and they provide a versatile framework suitable for various cellular assays, including drug screening and phenotypic analysis.
For researchers and clinicians, the value of PREX1 Gene Knockout Cell Lines extends beyond mere genetic manipulation; they serve as essential tools in the quest to unravel the complexities of cancer biology and therapeutic resistance. By leveraging these advanced cell lines, professionals can drive innovation and enhance the pace of discovery in cancer research.
Our company excels in the development of cutting-edge biological tools, providing high-quality gene knockout cell lines that empower researchers to delve deeper into the genetic underpinnings of disease. With a commitment to scientific excellence and innovation, we ensure that our products meet the highest standards of reliability and efficacy for impactful research.
Please note that all services are for research use only. Not intended for any clinical use.
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