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PPP4R1 Knockout Cell Lines

Gene: PPP4R1

Official Full Name: protein phosphatase 4 regulatory subunit 1provided by HGNC

Gene Summary: This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32418 PPP4R1 Knockout cell line (HeLa) Human PPP4R1 1:3~1:6 Negative Online Inquiry
KO32419 PPP4R1 Knockout cell line (HCT 116) Human PPP4R1 1:2~1:4 Negative Online Inquiry
KO32420 PPP4R1 Knockout cell line (HEK293) Human PPP4R1 1:3~1:6 Negative Online Inquiry
KO32421 PPP4R1 Knockout cell line (A549) Human PPP4R1 1:3~1:4 Negative Online Inquiry

Background

PPP4R1 Gene Knockout Cell Lines represent a groundbreaking tool in the field of genetic research, specifically designed to study the role and function of the PPP4R1 gene. These cell lines have been genetically modified to disrupt the expression of the PPP4R1 protein, which is a pivotal regulatory subunit of protein phosphatase 4 (PP4). This knockout facilitates researchers in elucidating the biological pathways and processes influenced by PPP4R1, commonly involved in cellular responses to stress, apoptosis, and gene expression regulation.

The primary mechanism of action is the absence of PPP4R1, which leads to altered signaling cascades and downstream effects on various phosphatase activities within the cell. By utilizing these knockout cell lines, researchers can effectively mimic pathological conditions where PPP4R1 is downregulated or dysfunctional. This is particularly crucial in studying cancer biology, neurodegenerative disorders, and other diseases where the PP4 pathway plays a critical role.

The scientific importance of PPP4R1 Gene Knockout Cell Lines extends to their applications in basic and translational research, allowing investigators to design targeted experiments to evaluate the gene's contributions to cellular function and disease mechanisms. This versatility makes them ideal for application in drug discovery and for the development of therapeutic strategies aimed at restoring normal cellular function.

Compared to conventional cell lines, the unique selling points of PPP4R1 Gene Knockout Cell Lines lie in their specificity and reliability. Researchers are often faced with the challenge of data variability; these knockout models provide a more consistent platform to study gene function and provide insights that might be missed with wild-type or non-specific models. Moreover, these cell lines can be easily cultured and utilized in routine laboratory settings, ensuring practicality for research teams.

In conclusion, PPP4R1 Gene Knockout Cell Lines represent a valuable advancement for researchers and clinicians seeking to unravel the complexities of cellular signaling. They will undoubtedly accelerate the pace of discovery in molecular biology and therapeutic development. Our company, with its commitment to pioneering biological products and innovative genetic tools, is dedicated to supporting the scientific community in achieving transformative research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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