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PPP2R5A Knockout Cell Lines

Gene: PPP2R5A

Official Full Name: protein phosphatase 2 regulatory subunit B'alphaprovided by HGNC

Gene Summary: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10181 PPP2R5A Knockout cell line (HeLa) Human PPP2R5A 1:3~1:6 Negative Online Inquiry
KO10182 PPP2R5A Knockout cell line (HCT 116) Human PPP2R5A 1:2~1:4 Negative Online Inquiry
KO10183 PPP2R5A Knockout cell line (HEK293) Human PPP2R5A 1:3~1:6 Negative Online Inquiry
KO10184 PPP2R5A Knockout cell line (A549) Human PPP2R5A 1:3~1:4 Negative Online Inquiry

Background

PPP2R5A Gene Knockout Cell Lines represent a significant advancement in molecular biology, specifically designed to facilitate the study of the protein phosphatase 2A (PP2A) regulatory subunit. By employing CRISPR-Cas9 technology, these knockout cell lines effectively disable the PPP2R5A gene, which encodes for a critical component of the PP2A holoenzyme complex. This gene plays a vital role in various cellular processes, including cell cycle regulation, signal transduction, and apoptosis. The resulting knockout cells enable researchers to dissect the specific functions of the PPP2R5A subunit, thereby elucidating its contributions to cellular homeostasis and disease states.

The primary function of these knockout cell lines lies in their ability to provide a platform for studying the mechanistic pathways that involve PP2A and its role in tumorigenesis, neurodegenerative disorders, and other pathologies. Their robust design allows for the examination of alterations in signaling pathways upon the loss of PPP2R5A, making them invaluable for functional assays and drug discovery. Importantly, they can be employed in both in vitro and in vivo experiments, thereby bridging the gap between basic research and therapeutic applications.

What sets our PPP2R5A Gene Knockout Cell Lines apart from alternatives is their consistent performance and reliability, validated through rigorous testing and characterization. Users will benefit from a streamlined workflow that accelerates research timelines and bolsters reproducibility. Furthermore, these knockout cell lines are adaptable to various experimental setups, providing versatility that is essential for clinicians and researchers exploring the complexities of cellular signaling.

The value of PPP2R5A Gene Knockout Cell Lines extends beyond basic research; they have the potential to inform therapeutic strategies and pave the way for novel drug development aimed at diseases linked to PP2A dysfunction. By utilizing these cell lines, researchers and clinicians can uncover insights that directly impact patient care and treatment methodologies.

Our company prides itself on delivering high-quality biological products, backed by years of expertise in genetic engineering and cell line development. We are committed to supporting scientific discovery and innovation through reliable tools that empower the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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