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PPP2R3C Knockout Cell Lines

Gene: PPP2R3C

Official Full Name: protein phosphatase 2 regulatory subunit B''gammaprovided by HGNC

Gene Summary: This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07623 PPP2R3C Knockout cell line (HeLa) Human PPP2R3C 1:3~1:6 Negative Online Inquiry
KO07624 PPP2R3C Knockout cell line (HCT 116) Human PPP2R3C 1:2~1:4 Negative Online Inquiry
KO07625 PPP2R3C Knockout cell line (HEK293) Human PPP2R3C 1:3~1:6 Negative Online Inquiry
KO07626 PPP2R3C Knockout cell line (A549) Human PPP2R3C 1:3~1:4 Negative Online Inquiry

Background

PPP2R3C Gene Knockout Cell Lines are sophisticated biological tools designed to facilitate the study of the PPP2R3C gene's role in cellular processes. These cell lines are genetically engineered to have a complete loss-of-function mutation of the PPP2R3C gene, which encodes a regulatory subunit of the protein phosphatase 2A (PP2A) complex. The manipulation of this gene allows for in-depth investigation into its influence on various signaling pathways, cellular division, and response to stress, making it crucial for understanding the molecular mechanisms underlying many diseases, including cancer.

The primary function of the PPP2R3C gene knockout is to disrupt normal PP2A activity, which plays a pivotal role in multiple cellular processes, including but not limited to, cell growth, apoptosis, and protein signaling. By studying these knockout cell lines, researchers can elucidate the consequences of PP2A dysregulation, revealing potential therapeutic targets and biomarkers for diseases influenced by this pathway.

Scientifically, these cell lines are invaluable in both research and clinical settings as they provide a model for elucidating the intricate roles of PP2A and its regulatory subunits. The ability to study loss-of-function alterations helps in understanding pathological conditions and supports drug discovery efforts aimed at targeting PP2A-related mechanisms.

What sets our PPP2R3C Gene Knockout Cell Lines apart from alternatives is their high specificity and reliability. Each cell line is rigorously validated, ensuring consistent outcomes across studies. This reliability not only enhances reproducibility but also reduces variability in experimental results, which is increasingly important in today’s high-stakes research environments.

Researchers, clinicians, and pharmaceutical companies benefit significantly from the use of our knockout cell lines, as they provide a clear and accurate understanding of the PPP2R3C gene's function, subsequently accelerating the progression from basic research to the clinic. Our company boasts extensive experience in genetic engineering and cell line development, ensuring that our products meet the highest standards of quality and scientific rigor.

Please note that all services are for research use only. Not intended for any clinical use.

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