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PPME1 Knockout Cell Lines

Gene: PPME1

Official Full Name: protein phosphatase methylesterase 1provided by HGNC

Gene Summary: This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22560 PPME1 Knockout cell line (HeLa) Human PPME1 1:3~1:6 Negative Online Inquiry
KO22561 PPME1 Knockout cell line (HCT 116) Human PPME1 1:2~1:4 Negative Online Inquiry
KO22562 PPME1 Knockout cell line (HEK293) Human PPME1 1:3~1:6 Negative Online Inquiry
KO22563 PPME1 Knockout cell line (A549) Human PPME1 1:3~1:4 Negative Online Inquiry

Background

PPME1 Gene Knockout Cell Lines are specialized cellular models developed to study the functional implications of the PPME1 gene, known for its role in protein phosphatase regulation and cellular signaling processes. These knockout cell lines are generated through targeted gene-editing techniques, such as CRISPR-Cas9, which ensures the precise disruption of the PPME1 gene, rendering it nonfunctional. This creates a unique platform for researchers to investigate the biological pathways and molecular interactions influenced by PPME1, thereby elucidating its contributions to various physiological and pathological contexts.

The primary function of these cell lines is to facilitate the characterization of phenotypic changes resulting from the absence of PPME1. By providing a tool to study gene function, they allow scientists to explore alterations in cellular behaviors, including proliferation, differentiation, and response to external stimuli. The knockout models are particularly valuable for assessing the role of PPME1 in disease mechanisms, such as cancer progression and neurodegenerative disorders, where its regulatory influence is thought to be pivotal.

The scientific importance of PPME1 Gene Knockout Cell Lines extends to both research and clinical applications. In research, they enable high-throughput screening for potential drug candidates and the development of targeted therapies. Clinically, these models offer insights into patient-specific responses to treatments, enhancing personalized medicine approaches.

One of the unique selling points of these knockout cell lines is their reliability and reproducibility compared to alternative models that may exhibit background variations due to partial gene expression or inherent genetic plasticity. By utilizing these cell lines, researchers can achieve a higher degree of specificity in their studies, leading to more robust data and interpretations.

For researchers and clinicians alike, the PPME1 Gene Knockout Cell Lines empower them to uncover underlying disease mechanisms and innovate therapeutic strategies. The expertise of our company in producing high-quality gene-editing cell models ensures that you receive a product that meets the stringent needs of modern biological research. Our commitment to excellence in research tools allows scientists to push the boundaries of discovery while enhancing the translational impact of their work.

Please note that all services are for research use only. Not intended for any clinical use.

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