Gene: PPM1A
Official Full Name: protein phosphatase, Mg2+/Mn2+ dependent 1Aprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10559 | PPM1A Knockout cell line (HeLa) | Human | PPM1A | 1:3~1:6 | Negative | Online Inquiry |
KO10560 | PPM1A Knockout cell line (HCT 116) | Human | PPM1A | 1:2~1:4 | Negative | Online Inquiry |
KO10561 | PPM1A Knockout cell line (HEK293) | Human | PPM1A | 1:3~1:6 | Negative | Online Inquiry |
KO10562 | PPM1A Knockout cell line (A549) | Human | PPM1A | 1:3~1:4 | Negative | Online Inquiry |
PPM1A Gene Knockout Cell Lines are specialized cell lines engineered to lack the expression of the PPM1A gene, which encodes a protein that plays a critical role in cellular stress response and immune regulation. These knockout models provide researchers with a powerful tool to elucidate the functions of PPM1A in various biological contexts, making them invaluable for both basic and applied research.
The key mechanism underlying the functionality of PPM1A knockout cell lines lies in the gene's regulatory role in dephosphorylating various substrates, influencing several pathways including those related to apoptosis, cell cycle control, and response to environmental stressors. By removing the PPM1A gene, researchers can study the resultant phenotypic and molecular alterations, thereby gaining insights into its contributions to diseases such as cancer and autoimmune disorders.
The scientific importance of PPM1A knockout cell lines extends across multiple domains, from genetic studies to therapeutic development. They serve as vital platforms for drug screening, enabling the identification of compounds that target alternative pathways affected by the absence of PPM1A. Additionally, these cell lines can facilitate the understanding of drug resistance mechanisms, guiding the development of more effective treatment strategies.
One of the standout advantages of our PPM1A Gene Knockout Cell Lines is their high specificity and reproducibility, ensuring consistent results across experiments. Unlike conventional knockout models, which may have off-target effects or lack complete gene removal, our cell lines undergo rigorous validation, allowing researchers to trust their findings fully. Furthermore, integrating these knockout lines with advanced CRISPR and gene editing technologies can lead to novel applications and deeper biological insights.
For researchers, clinicians, and pharmaceutical companies, PPM1A Gene Knockout Cell Lines represent an essential asset in dissecting molecular pathways and advancing therapeutic innovations. At [Your Company Name], we pride ourselves on our commitment to quality and expertise in developing high-fidelity biological research tools, ensuring that our products meet the rigorous demands of today's scientific inquiries.
Please note that all services are for research use only. Not intended for any clinical use.
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