Gene: PPIB
Official Full Name: peptidylprolyl isomerase Bprovided by HGNC
Gene Summary: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02011 | PPIB Knockout cell line (HeLa) | Human | PPIB | 1:3~1:6 | Negative | Online Inquiry |
KO02012 | PPIB Knockout cell line (HCT 116) | Human | PPIB | 1:2~1:4 | Negative | Online Inquiry |
KO02013 | PPIB Knockout cell line (HEK293) | Human | PPIB | 1:3~1:6 | Negative | Online Inquiry |
KO02014 | PPIB Knockout cell line (A549) | Human | PPIB | 1:3~1:4 | Negative | Online Inquiry |
PPIB Gene Knockout Cell Lines are genetically modified cell lines designed to facilitate the study of the PPIB gene, which encodes the peptidyl-prolyl isomerase B enzyme. This enzyme plays a critical role in protein folding and is implicated in various cellular processes, including signal transduction and immune response modulation. By creating knockout cell lines, researchers can observe the effects of PPIB gene loss on cellular function, providing insights into the gene's role in health and disease.
These cell lines have been engineered through advanced CRISPR-Cas9 gene-editing technology, ensuring precise and efficient disruption of the PPIB gene. As a result, they serve as valuable tools for investigating the mechanisms underlying diseases associated with dysfunctional protein folding, such as certain cancers and neurodegenerative diseases. This knockout model allows for the examination of compensatory pathways and the elucidation of the PPIB gene's contributions to cellular homeostasis, enabling researchers to draw more accurate conclusions regarding cellular behavior.
The scientific importance of PPIB Gene Knockout Cell Lines extends into both fundamental research and clinical applications. They can be employed in drug discovery processes, aiding the development of therapeutics targeting aberrant protein folding and providing a platform for testing the efficacy of novel compounds. Furthermore, their use can enhance our understanding of genetic disorders linked to PPIB dysfunction, informing diagnostics and potential treatments.
One of the distinct advantages of these cell lines is their versatility; they can be employed in a variety of experimental setups, including high-throughput screening and gene expression studies. Moreover, the precise nature of the gene knockout and the cell lines’ reliable performance make them superior alternatives to traditional knockout models, which often suffer from off-target effects and variable expression.
For researchers and clinicians alike, PPIB Gene Knockout Cell Lines offer a reliable and effective means to dissect the complexities of gene function and its implications in disease. With their ability to facilitate novel discoveries and therapeutic advancements, they represent a vital addition to any laboratory focused on molecular biology or translational research.
Our company specializes in providing cutting-edge genetically modified cell lines that meet the highest standards of quality and reliability. With a commitment to advancing scientific research, we ensure our products support the innovative efforts of researchers and clinicians worldwide.
Please note that all services are for research use only. Not intended for any clinical use.
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