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POU2F1 Knockout Cell Lines

Gene: POU2F1

Official Full Name: POU class 2 homeobox 1provided by HGNC

Gene Summary: The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35967 POU2F1 Knockout cell line (HeLa) Human POU2F1 1:3~1:6 Negative Online Inquiry
KO35968 POU2F1 Knockout cell line (HCT 116) Human POU2F1 1:2~1:4 Negative Online Inquiry
KO35969 POU2F1 Knockout cell line (HEK293) Human POU2F1 1:3~1:6 Negative Online Inquiry
KO35970 POU2F1 Knockout cell line (A549) Human POU2F1 1:3~1:4 Negative Online Inquiry

Background

POU2F1 Gene Knockout Cell Lines are genetically engineered cell lines that have been developed to specifically inhibit the expression of the POU2F1 gene, which encodes a transcription factor crucial for B-cell development and function. These knockout cell lines serve as a powerful tool in molecular biology research, particularly in studies focusing on gene function and regulatory mechanisms in immunology and hematopoiesis.

The key functions of the POU2F1 knockout cell lines revolve around their ability to elucidate the role of POU2F1 in various cellular processes. By removing this gene's expression, researchers can study the downstream effects on cellular signaling pathways, gene expression profiles, and the overall impact on B-cell maturation and response to antigens. This enables scientists to examine the gene's involvement in conditions such as immune deficiencies, leukemia, and other hematological disorders.

The scientific importance of POU2F1 knockout cell lines extends to both research and clinical applications. In research settings, they are invaluable for exploring transcriptional regulation and the molecular interactions influenced by POU2F1, while in the clinical context, these models can aid in the development of targeted therapies and personalized medicine approaches.

Compared to alternative cell lines, POU2F1 knockout models offer significant advantages, including high specificity for the POU2F1 gene and the potential for reproducible results in functional assays. The precise gene-editing techniques used to develop these knockout lines ensure minimal off-target effects, providing researchers with confidence in their findings.

For researchers and clinicians, the value of POU2F1 Gene Knockout Cell Lines lies in their ability to unlock critical insights into B-cell biology and associated diseases. By offering a reliable experimental platform, they help advance our understanding of immune system functioning, paving the way for innovative therapeutic strategies.

Our company specializes in the development of cutting-edge genetic tools and cell line models designed to support scientific discovery. With a commitment to quality and precision, we empower researchers with reliable solutions that drive progress in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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