Gene: POM121
Official Full Name: POM121 transmembrane nucleoporinprovided by HGNC
Gene Summary: This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04678 | POM121 Knockout cell line (HeLa) | Human | POM121 | 1:3~1:6 | Negative | Online Inquiry |
KO04679 | POM121 Knockout cell line (HCT 116) | Human | POM121 | 1:2~1:4 | Negative | Online Inquiry |
KO04680 | POM121 Knockout cell line (HEK293) | Human | POM121 | 1:3~1:6 | Negative | Online Inquiry |
KO04681 | POM121 Knockout cell line (A549) | Human | POM121 | 1:3~1:4 | Negative | Online Inquiry |
POM121 Gene Knockout Cell Lines are advanced cellular models specifically engineered to lack the POM121 gene, a crucial component of the nuclear pore complex. This gene plays a significant role in nucleocytoplasmic transport, mediating the passage of proteins and RNA between the nucleus and cytoplasm. By employing CRISPR/Cas9 gene-editing technology, these cell lines have been meticulously developed to provide researchers with a powerful tool to study the consequences of POM121 depletion on cellular functions, interactions, and overall gene expression.
The primary function of POM121 Gene Knockout Cell Lines is to facilitate the investigation of the molecular mechanisms underlying nuclear transport and its implications in various physiological and pathological conditions. By observing the effects of the knockout on these processes, researchers can draw critical insights into the role of POM121 in cellular homeostasis, the cell cycle, and potential links to diseases—such as cancer—where nuclear transport is often dysregulated.
The significance of these cell lines extends far beyond basic research; they hold immense potential for applications in drug development and therapeutic research. Understanding the dynamics of nuclear pore complexes can aid in the design of targeted therapies for diseases involving aberrant nuclear transport mechanisms.
What sets POM121 Gene Knockout Cell Lines apart from alternative models is their unparalleled specificity and reliability. Unlike other generic knockouts, these cell lines are rigorously validated, ensuring that the absence of the POM121 gene is complete and reproducible, thus providing more reliable experimental outcomes. Moreover, they are adaptable for a range of assays, including gene expression studies, drug assays, and protein localization investigations, making them a versatile addition to any laboratory.
For researchers and clinicians focusing on cellular transport mechanisms and their broader implications, the POM121 Gene Knockout Cell Lines represent an invaluable resource. With our company's dedication to precision gene editing and robust product quality, we offer expertise that empowers scientific discovery and innovation in your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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