Gene: POLR2J2
Official Full Name: RNA polymerase II subunit J2provided by HGNC
Gene Summary: This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21458 | POLR2J2 Knockout cell line (HCT 116) | Human | POLR2J2 | 1:2~1:4 | Negative | Online Inquiry |
KO21459 | POLR2J2 Knockout cell line (HEK293) | Human | POLR2J2 | 1:3~1:6 | Negative | Online Inquiry |
POLR2J2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the POLR2J2 gene, which encodes a component of RNA polymerase II. This enzyme is essential for synthesizing messenger RNA (mRNA) in eukaryotic cells, thereby playing a pivotal role in gene expression regulation. By utilizing these knockout cell lines, researchers can study the impact of POLR2J2 deficiency on cellular processes, including transcriptional regulation and mRNA processing.
The key functions of POLR2J2 are linked to its involvement in mediating the transcription of protein-coding genes. Its absence elucidates the contributions of RNA polymerase II to various cellular mechanisms, such as growth, differentiation, and response to environmental stimuli. Through careful experimentation with these cell lines, researchers can uncover the downstream effects of disrupted gene expression, therefore contributing to a comprehensive understanding of cellular biology and disease mechanisms.
The scientific importance of POLR2J2 Gene Knockout Cell Lines extends to a variety of research applications, including cancer biology, developmental biology, and neurobiology. In clinical research, these models enable scientists to examine the potential roles of POLR2J2 in pathologies such as malignancies or neurodegenerative diseases, paving the way for targeted therapeutic strategies.
What sets these cell lines apart from alternatives is their precise genetic modification and robust reliability in experimental settings. They provide an unparalleled platform for investigating the nuances of gene function and interaction without the variability often observed in less targeted models. Furthermore, the availability of these specific knockout lines can accelerate the pace of research, allowing for faster hypothesis testing and validation.
For researchers and clinicians looking to deepen their understanding of transcriptional regulation and its implications in health and disease, POLR2J2 Gene Knockout Cell Lines offer a crucial tool. Our company has dedicated itself to providing high-quality, genetically altered cell lines that meet rigorous scientific standards, ensuring that our products support groundbreaking research and innovation in the biological sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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