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POGLUT1 Knockout Cell Lines

Gene: POGLUT1

Official Full Name: protein O-glucosyltransferase 1provided by HGNC

Gene Summary: This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07077 POGLUT1 Knockout cell line (HeLa) Human POGLUT1 1:3~1:6 Negative Online Inquiry
KO07078 POGLUT1 Knockout cell line (HCT 116) Human POGLUT1 1:2~1:4 Negative Online Inquiry
KO07079 POGLUT1 Knockout cell line (HEK293) Human POGLUT1 1:3~1:6 Negative Online Inquiry
KO07080 POGLUT1 Knockout cell line (A549) Human POGLUT1 1:3~1:4 Negative Online Inquiry

Background

POGLUT1 Gene Knockout Cell Lines are specialized genetically modified cell lines designed to facilitate comprehensive research on the POGLUT1 gene's role in cellular processes and disease mechanisms. These cell lines are generated using state-of-the-art CRISPR/Cas9 technology, which allows for precise gene editing to create a complete knockout of the POGLUT1 gene, resulting in the elimination of its functional protein expression. As a result, researchers can investigate the direct consequences of this gene’s absence, providing crucial insights into its biological functions and potential implications in various pathological conditions.

The primary function of POGLUT1 is to participate in O-linked glycosylation, a post-translational modification critical for diverse cellular activities, including protein stability, signaling, and membrane transport. By utilizing POGLUT1 Gene Knockout Cell Lines, researchers can elucidate the molecular mechanisms by which POGLUT1 influences cellular signaling pathways and its contributions to diseases such as cancer, metabolic disorders, and neurodegenerative conditions.

In the realms of research and clinical applications, these cell lines serve as a powerful tool for understanding disease mechanisms, testing therapeutic strategies, and exploring gene function within a controlled environment. The specificity of the knockout ensures that any observed phenotypic changes can be attributed directly to the absence of the POGLUT1 protein, offering a level of precision often lacking in other experimental models.

What sets our POGLUT1 Gene Knockout Cell Lines apart from standard alternatives is their derived nature from well-characterized cellular backgrounds, ensuring consistency in experimental results. Additionally, the ease of use, together with the thoroughly validated knockout efficiency, empowers researchers to save time and resources while achieving reliable outcomes.

For researchers and clinicians focused on genetic and biochemical exploration, the POGLUT1 Gene Knockout Cell Lines provide an invaluable resource that enhances understanding and drives innovation in targeted therapies. Our company prides itself on delivering high-quality biological products and maintains a commitment to advancing life science research through rigorous validation and expertise in genetic engineering technologies.

Please note that all services are for research use only. Not intended for any clinical use.

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