Gene: PLD1
Official Full Name: phospholipase D1provided by HGNC
Gene Summary: This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08908 | PLD1 Knockout cell line (HeLa) | Human | PLD1 | 1:3~1:6 | Negative | Online Inquiry |
KO08909 | PLD1 Knockout cell line (HCT 116) | Human | PLD1 | 1:2~1:4 | Negative | Online Inquiry |
KO08910 | PLD1 Knockout cell line (HEK293) | Human | PLD1 | 1:3~1:6 | Negative | Online Inquiry |
KO08911 | PLD1 Knockout cell line (A549) | Human | PLD1 | 1:3~1:4 | Negative | Online Inquiry |
PLD1 Gene Knockout Cell Lines are specialized cellular models engineered to specifically disrupt the expression of the phospholipase D1 (PLD1) gene. This gene encodes an enzyme involved in lipid signaling and plays a significant role in various biological processes, including cell proliferation, migration, and survival. By utilizing CRISPR/Cas9 gene-editing technology, these knockout cell lines are designed to provide a powerful tool for researchers investigating the functional consequences of PLD1 loss in various cellular contexts.
The key functions of the PLD1 Gene Knockout Cell Lines revolve around their ability to elucidate the physiological and pathological roles of PLD1 in cellular signaling pathways. Researchers can assess how the absence of this enzyme affects lipid metabolism, cellular responses to growth factors, and the regulation of cytoskeletal dynamics. Mechanistically, the knockout of PLD1 facilitates the study of downstream signaling alterations and assists in determining the gene's implications in diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions.
Scientifically, PLD1's role has been implicated in critical applications, from understanding tumor biology to exploring the mechanisms of cell migration and invasion, making this product invaluable in both academic and clinical settings. Its utilization can lead to the identification of novel therapeutic targets and biomarkers.
Compared to traditional cell lines that express PLD1, the knockout variants provide a definitive tool for direct comparisons, allowing researchers to isolate specific effects attributable to PLD1 nullification. This unique functionality allows for streamlined experimental designs and enhances the robustness of data interpretation.
For researchers and clinicians, the value of these cell lines lies in their ability to provide a clear understanding of the biological implications of PLD1, driving innovative discoveries and potential therapeutic interventions. By integrating these cutting-edge model systems into your research pipeline, you can significantly amplify your experimental outcomes and accelerate the pace of discovery.
Our company specializes in developing high-quality biological products that empower scientific exploration. With our expertise in gene knockout technologies, we are committed to supporting researchers in advancing knowledge and finding solutions in biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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