Gene: PLCG1
Official Full Name: phospholipase C gamma 1provided by HGNC
Gene Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11016 | PLCG1 Knockout cell line (HeLa) | Human | PLCG1 | 1:3~1:6 | Negative | Online Inquiry |
KO11017 | PLCG1 Knockout cell line (HCT 116) | Human | PLCG1 | 1:2~1:4 | Negative | Online Inquiry |
KO11018 | PLCG1 Knockout cell line (HEK293) | Human | PLCG1 | 1:3~1:6 | Negative | Online Inquiry |
KO11019 | PLCG1 Knockout cell line (A549) | Human | PLCG1 | 1:3~1:4 | Negative | Online Inquiry |
PLCG1 Gene Knockout Cell Lines are specifically engineered cellular models in which the phospholipase C gamma 1 (PLCG1) gene has been inactivated through targeted gene editing techniques. These knockout cell lines provide invaluable tools for researchers investigating the role of PLCG1 in various signaling pathways and cellular processes, including cell growth, differentiation, and apoptosis. The mechanism behind their utilization stems from the central role PLCG1 plays in the phosphoinositide signaling pathway, which is crucial for mediating cellular responses to external stimuli.
The scientific significance of PLCG1 knockout cell lines lies in their application across multiple research fields, including cancer biology, immunology, and neurobiology. By studying the functional implications of PLCG1 deficiency, researchers can unravel the complexities of signal transduction related to various pathologies, uncover novel therapeutic targets, and enhance the understanding of disease mechanisms. Furthermore, these cell lines facilitate dose-response studies and pharmacological assessments, making them essential for preclinical drug development.
One standout advantage of PLCG1 Gene Knockout Cell Lines is their specificity and reliability. Unlike traditional cell lines, which may retain partial functional PLCG1, these knockout models ensure a complete loss-of-function, allowing for more robust experimental outcomes. Additionally, they provide an innovative platform for gene editing validation and high-throughput screening applications, setting them apart from alternatives that may yield inconsistent results.
For researchers and clinicians seeking detailed insights into the role of phosphoinositide signaling in health and disease, PLCG1 Gene Knockout Cell Lines represent a transformative tool that accelerates discovery and drives innovation. With our company’s extensive expertise in cellular engineering and commitment to delivering high-quality biological products, we are dedicated to supporting your research endeavors by providing unparalleled access to these advanced model systems.
Please note that all services are for research use only. Not intended for any clinical use.
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