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PITRM1 Knockout Cell Lines

Gene: PITRM1

Official Full Name: pitrilysin metallopeptidase 1provided by HGNC

Gene Summary: The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31731 PITRM1 Knockout cell line (HeLa) Human PITRM1 1:3~1:6 Negative Online Inquiry
KO31732 PITRM1 Knockout cell line (HCT 116) Human PITRM1 1:2~1:4 Negative Online Inquiry
KO31733 PITRM1 Knockout cell line (HEK293) Human PITRM1 1:3~1:6 Negative Online Inquiry
KO31734 PITRM1 Knockout cell line (A549) Human PITRM1 1:3~1:4 Negative Online Inquiry

Background

PITRM1 Gene Knockout Cell Lines are genetically engineered cell lines designed to explore the role of the PITRM1 gene in various biological processes. This gene encodes a mitochondrial matrix intermediary peptidase that is vital for protein maturation and cellular metabolism. By knocking out the PITRM1 gene, researchers can investigate the subsequent effects on cellular function, mitochondrial dynamics, and the regulation of key metabolic pathways, providing insights into diseases related to mitochondrial dysfunction and aging.

The fundamental mechanism of these knockout cell lines hinges on the precise ablation of the PITRM1 gene, which allows for the assessment of cellular responses and compensatory mechanisms in the absence of this critical enzyme. Researchers can utilize these cell lines to explore how the disruption affects mitochondrial protein turnover, energy metabolism, and the broader implications on cellular health and longevity. This makes PITRM1 knockout cell lines an invaluable tool for studies in mitochondrial biology, neurodegenerative diseases, and metabolic disorders.

The scientific importance of these cell lines extends to both research and clinical applications. They can be employed in drug screening efforts, permitting the identification of potential therapeutic agents targeting metabolic pathways affected by PITRM1 dysfunction. Additionally, they may aid in understanding how variations in this gene contribute to personalized medicine approaches.

One of the key advantages of our PITRM1 Gene Knockout Cell Lines is the high specificity and efficiency of the knockout technology employed, ensuring reliable results and reproducibility. Compared to alternative models, our cell lines exhibit enhanced metabolic profiling capabilities, allowing researchers to draw more profound and relevant conclusions.

This product is particularly valuable for researchers and clinicians who are investigating the underlying mechanisms of diseases linked to mitochondrial impairments, providing unprecedented experimental models to unravel complex biological questions. Understanding the role of PITRM1 in cellular processes can lead to innovative approaches in disease prevention and treatment.

With our longstanding commitment to excellence in biological research tools, our company offers a robust portfolio of high-quality genetic models that enhance scientific discovery and facilitate advanced research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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