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PIP4P2 Knockout Cell Lines

Gene: PIP4P2

Official Full Name: phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2provided by HGNC

Gene Summary: TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07840 PIP4P2 Knockout cell line (HeLa) Human PIP4P2 1:3~1:6 Negative Online Inquiry
KO07841 PIP4P2 Knockout cell line (HCT 116) Human PIP4P2 1:2~1:4 Negative Online Inquiry
KO07842 PIP4P2 Knockout cell line (HEK293) Human PIP4P2 1:3~1:6 Negative Online Inquiry
KO07843 PIP4P2 Knockout cell line (A549) Human PIP4P2 1:3~1:4 Negative Online Inquiry

Background

PIP4P2 Gene Knockout Cell Lines are genetically engineered cell models that have been specifically designed to enable the study of the phosphoinositide phosphatase PIP4P2. This gene encodes an enzyme that plays a crucial role in the regulation of various intracellular signaling pathways through the metabolism of phosphoinositides. By knocking out the PIP4P2 gene, these cell lines allow researchers to elucidate its functional implications in cellular processes such as membrane trafficking, cell proliferation, and apoptosis.

The primary mechanism of this product involves CRISPR-Cas9 technology, which facilitates precise editing of the genome to create a loss-of-function mutation. This targeted approach enables scientists to observe the phenotypic changes that arise from the absence of PIP4P2, providing crucial insights into its biological role and potential pathological connections. The cells can be used across multiple research fields, including cancer biology, neurobiology, and metabolic disorders, making them a versatile tool in laboratory investigations.

The scientific importance of PIP4P2 Gene Knockout Cell Lines lies in their ability to model diseases associated with disrupted phosphoinositide signaling, while also serving as a platform for drug discovery and development. Compared to traditional methods, these knockout cell lines provide a more efficient and accurate means of investigating gene function without the complications of compensatory mechanisms.

Researchers and clinicians navigating the complexities of cellular signaling will find these cell lines invaluable due to their specificity, reproducibility, and ease of use in experimental setups. They can expedite research timelines and enhance the robustness of experimental data, ultimately leading to a deeper understanding of pathogenetic mechanisms.

Our company boasts extensive expertise in gene editing technologies and offers a range of high-quality biological products aimed at facilitating groundbreaking research. With a commitment to innovation and scientific rigor, we ensure that our PIP4P2 Gene Knockout Cell Lines meet the highest standards for researchers and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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