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PILRA Knockout Cell Lines

Gene: PILRA

Official Full Name: paired immunoglobin like type 2 receptor alphaprovided by HGNC

Gene Summary: Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26854 PILRA Knockout cell line (HeLa) Human PILRA 1:3~1:6 Negative Online Inquiry
KO26855 PILRA Knockout cell line (HEK293) Human PILRA 1:3~1:6 Negative Online Inquiry
KO26856 PILRA Knockout cell line (A549) Human PILRA 1:3~1:4 Negative Online Inquiry

Background

PILRA Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to silence the PILRA (Paired Immunoglobulin-Like Type 2 Receptor Alpha) gene. These knockout models provide researchers with a powerful tool for studying the functional implications of PILRA in immune response and its role in various pathologies, particularly those involving immune evasion and tumor microenvironments. By developing these models, understanding how PILRA contributes to immune modulation has become increasingly accessible.

The key function of PILRA Gene Knockout Cell Lines lies in their ability to elucidate the molecular mechanisms through which PILRA influences immune cell activation, cytokine production, and overall immune homeostasis. In the context of tumor biology, for instance, these cell lines facilitate the exploration of how PILRA signaling pathways may alter tumor-immune interactions, allowing for a more comprehensive understanding of cancer progression and potential therapeutic targets.

The scientific importance of these cell lines extends beyond basic research; they are pivotal in developing novel immunotherapeutic strategies. For clinical applications, understanding PILRA's role can inform treatment regimens that aim to enhance immune responses against tumors or chronic infections where PILRA-mediated suppression is a factor.

Compared to traditional methods such as pharmacological inhibition, our PILRA Gene Knockout Cell Lines offer specificity and consistency, minimizing off-target effects. This precise genetic modification presents a unique selling point for researchers seeking reliable and reproducible results in their studies.

For researchers and clinicians alike, having access to these specialized cell lines opens doors to invaluable insights into immune biology. Given the growing interest in immunotherapy and personalized medicine, our PILRA Gene Knockout Cell Lines provide a significant advantage in advancing scientific knowledge and developing innovative therapeutic approaches.

At [Your Company Name], we pride ourselves on our commitment to excellence in biological research tools, delivering high-quality cell lines that meet the evolving needs of the scientific community. Our expertise in genetic engineering ensures that our products are not only cutting-edge but also tailored to suit the specific demands of rigorous research environments.

Please note that all services are for research use only. Not intended for any clinical use.

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