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PHLDB2 Knockout Cell Lines

Gene: PHLDB2

Official Full Name: pleckstrin homology like domain family B member 2provided by HGNC

Gene Summary: Enables cadherin binding activity. Involved in several processes, including negative regulation of focal adhesion assembly; regulation of cytoskeleton organization; and regulation of embryonic development. Located in several cellular components, including basal cortex; cytoskeleton; and focal adhesion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23849 PHLDB2 Knockout cell line (HeLa) Human PHLDB2 1:3~1:6 Negative Online Inquiry
KO23850 PHLDB2 Knockout cell line (HCT 116) Human PHLDB2 1:2~1:4 Negative Online Inquiry
KO23851 PHLDB2 Knockout cell line (HEK293) Human PHLDB2 1:3~1:6 Negative Online Inquiry
KO23852 PHLDB2 Knockout cell line (A549) Human PHLDB2 1:3~1:4 Negative Online Inquiry

Background

PHLDB2 Gene Knockout Cell Lines are sophisticated, engineered cellular models specifically designed for the functional study of the PHLDB2 gene, which is involved in various cellular processes, including cell signaling and apoptosis. These knockout cell lines feature a targeted disruption of the PHLDB2 gene, allowing researchers to investigate the gene’s role in both normal physiology and pathological conditions.

The key function of these cell lines lies in their ability to provide insights into the biological consequences of PHLDB2 loss. By utilizing CRISPR/Cas9 gene-editing technology, the knockout lines exhibit a complete absence of the PHLDB2 protein, facilitating dynamic studies on cellular behavior, gene expression profiles, metabolic pathways, and responses to therapeutic agents. Researchers can thereby explore the molecular mechanisms through which PHLDB2 influences tumorigenesis, cardiovascular diseases, and other health conditions.

The scientific importance of PHLDB2 Gene Knockout Cell Lines is underscored by their wide-ranging applications in biomedical research and drug development. These models can be instrumental in cancer research, enabling exploration of tumor biology and the evaluation of novel therapeutic strategies. Additionally, they may serve as platforms for biomarker discovery, contributing to personalized medicine approaches that rely on genetic variations.

What sets PHLDB2 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability. Conventional knockout methods often yield off-target effects, but the precision of CRISPR/Cas9 technology ensures that researchers obtain definitive results without unwanted genetic modifications. Moreover, these cell lines come with extensive characterization data, enhancing their credibility and facilitating reproducibility.

For researchers and clinicians focused on gene function and disease mechanisms, PHLDB2 Gene Knockout Cell Lines provide unparalleled value. Their use can accelerate the translation of bench-side discoveries to bedside applications, ultimately improving patient outcomes. As a trusted leader in the field of cellular models, our company remains committed to the ongoing development of innovative genetic tools, empowering the scientific community with reliable resources that drive impactful discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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