Gene: PHLDA2
Official Full Name: pleckstrin homology like domain family A member 2provided by HGNC
Gene Summary: This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02102 | PHLDA2 Knockout cell line (HeLa) | Human | PHLDA2 | 1:3~1:6 | Negative | Online Inquiry |
KO02103 | PHLDA2 Knockout cell line (HCT 116) | Human | PHLDA2 | 1:2~1:4 | Negative | Online Inquiry |
KO02104 | PHLDA2 Knockout cell line (HEK293) | Human | PHLDA2 | 1:3~1:6 | Negative | Online Inquiry |
KO02105 | PHLDA2 Knockout cell line (A549) | Human | PHLDA2 | 1:3~1:4 | Negative | Online Inquiry |
PHLDA2 Gene Knockout Cell Lines are engineered cellular models specifically designed for the in-depth study of the PHLDA2 gene, known for its involvement in various biological processes, including cellular growth regulation and apoptosis. By employing the CRISPR-Cas9 gene editing technology, these cell lines have had the PHLDA2 gene selectively disrupted, allowing researchers to investigate the consequences of its absence on cellular behavior and function.
The key function of the PHLDA2 Gene Knockout Cell Lines is to serve as a platform for exploring the molecular mechanisms underlying gene function and its role in diseases. For instance, PHLDA2 is implicated in mechanisms of tumor suppression and has been associated with various types of cancer. By utilizing these knockout models, researchers can elucidate the pathways activated or suppressed upon gene disruption, aiding in the identification of novel therapeutic targets and biomarkers.
In research and clinical settings, the PHLDA2 Gene Knockout Cell Lines represent a significant advancement for studies focused on cancer biology, developmental biology, and gene function. Their precise modification allows scientists to conduct more controlled experiments and obtain reliable data, minimizing variability often seen in wild-type cell lines.
Compared to alternative models, which may exhibit genetic variability or not accurately reflect the absence of PHLDA2, these specialized cell lines provide unique advantages. They offer a more reliable and reproducible system for experimentation, which is critical for validating hypotheses in the laboratory setting. Additionally, they can be easily integrated into existing workflows, facilitating research on gene-drug interactions and gene therapy approaches.
For researchers and clinicians, the PHLDA2 Gene Knockout Cell Lines are invaluable resources that streamline investigations into gene function, underpinning robust findings that contribute to the scientific community's understanding of genetic regulation and disease progression.
Our company is committed to advancing biological research through the provision of high-quality, genetically modified cell lines and reagents, ensuring that researchers have the tools necessary to drive innovation and discovery in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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