Gene: PHACTR3
Official Full Name: phosphatase and actin regulator 3provided by HGNC
Gene Summary: This gene encodes a member of the phosphatase and actin regulator protein family. The encoded protein is associated with the nuclear scaffold in proliferating cells, and binds to actin and the catalytic subunit of protein phosphatase-1, suggesting that it functions as a regulatory subunit of protein phosphatase-1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30552 | PHACTR3 Knockout cell line (HEK293) | Human | PHACTR3 | 1:3~1:6 | Negative | Online Inquiry |
PHACTR3 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the function of the PHACTR3 gene in various biological processes. By leveraging advanced CRISPR/Cas9 technology, these knockout cell lines have had the PHACTR3 gene disrupted, enabling researchers to investigate the role of PHACTR3 in cellular function and disease mechanisms. This gene is known to play a critical role in various cellular pathways, including regulation of actin dynamics and signal transduction, making it significant for studies related to cancer, cardiovascular diseases, and neurodegenerative disorders.
The mechanism behind the PHACTR3 knockout involves targeted gene editing, which results in the deletion or disruption of the gene's coding sequence, leading to a loss of protein function. As a consequence, researchers can observe phenotypic changes and assess the biological impact of PHACTR3 loss, using techniques such as flow cytometry, Western blotting, and microscopy. This functional analysis is pivotal in deciphering the gene's involvement in complex pathways and has far-reaching implications in both basic and applied research settings.
The scientific importance of PHACTR3 Gene Knockout Cell Lines lies in their application for drug discovery and development, as well as disease modeling. By understanding how the absence of PHACTR3 affects cellular behavior, researchers can identify potential therapeutic targets and pathways for intervention.
What sets these knockout cell lines apart from traditional models is their precision and adaptability. Unlike other gene manipulation methods that may leave residual expression, the CRISPR-based approach used ensures a complete knockout, providing more reliable data. Furthermore, these cell lines are available in various relevant backgrounds, ensuring compatibility with different experimental conditions.
The value of these PHACTR3 Gene Knockout Cell Lines is immense for researchers and clinicians aiming to advance their understanding of gene function in health and disease. By utilizing these tools, experts can develop and validate new hypotheses, leading to innovative treatments and strategies in precision medicine.
With a strong foundation in genetic engineering and molecular biology, our company is dedicated to providing high-quality biological products that empower researchers. We pride ourselves on our commitment to innovation, ensuring that our product offerings not only meet but exceed the standards of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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