Gene: PGPEP1
Official Full Name: pyroglutamyl-peptidase Iprovided by HGNC
Gene Summary: The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and other neuropeptides. Expression of this gene may be downregulated in colorectal cancer, while activity of the encoded protein may be negatively correlated with cancer progression in colorectal cancer patients. Activity of the encoded protease may also be altered in other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20757 | PGPEP1 Knockout cell line (HeLa) | Human | PGPEP1 | 1:3~1:6 | Negative | Online Inquiry |
KO20758 | PGPEP1 Knockout cell line (HCT 116) | Human | PGPEP1 | 1:2~1:4 | Negative | Online Inquiry |
KO20759 | PGPEP1 Knockout cell line (HEK293) | Human | PGPEP1 | 1:3~1:6 | Negative | Online Inquiry |
KO20760 | PGPEP1 Knockout cell line (A549) | Human | PGPEP1 | 1:3~1:4 | Negative | Online Inquiry |
PGPEP1 Gene Knockout Cell Lines are specialized cellular systems that have been genetically engineered to lack the expression of the PGPEP1 gene, which encodes the enzyme prolyl endopeptidase. This specific knockout allows researchers to study the functional impacts of PGPEP1 absence, enabling insights into its role in various biological processes, including protein metabolism and neuropeptide regulation.
The key function of PGPEP1 Gene Knockout Cell Lines lies in their ability to provide an experimental model for elucidating the physiological and pathological roles of the PGPEP1 enzyme. By employing CRISPR/Cas9 technology for precise gene editing, these cell lines facilitate controlled studies on how the absence of PGPEP1 affects cellular signaling pathways, neuronal activity, and overall cellular health. This model is particularly pertinent for understanding diseases where prolyl endopeptidase activity is implicated, such as certain neurodegenerative conditions and metabolic disorders.
From a scientific standpoint, PGPEP1 Gene Knockout Cell Lines play an essential role in both basic and applied research settings; they serve as valuable tools for drug discovery aimed at targeting neuropeptide-related mechanisms, as well as for screening compounds that may restore normal cellular function. The ability to study gene function in a controlled environment significantly enhances the ability of researchers and clinicians to design targeted therapeutic strategies.
One of the unique selling points of these cell lines is their high specificity and reliability compared to traditional models, such as chemical inhibitors or RNA interference techniques, which may produce off-target effects or incomplete gene silencing. Additionally, these knockout cell lines offer a reproducible and scalable platform, ensuring consistent results across experiments.
The value of PGPEP1 Gene Knockout Cell Lines to researchers and clinicians is profound. By providing an accurate representation of the genetic landscape and functional consequences of PGPEP1 absence, they empower users to uncover mechanisms that may lead to breakthrough treatments for complex diseases.
Our company's expertise in genetic engineering and cell line development underscores our commitment to providing researchers with high-quality, innovative biological products tailored to advance scientific discovery. With PGPEP1 Gene Knockout Cell Lines, we offer cutting-edge tools designed to accelerate research and facilitate the development of next-generation therapies.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.