Gene: PGBD4
Official Full Name: piggyBac transposable element derived 4provided by HGNC
Gene Summary: The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15212 | PGBD4 Knockout cell line (HeLa) | Human | PGBD4 | 1:3~1:6 | Negative | Online Inquiry |
KO15213 | PGBD4 Knockout cell line (HCT 116) | Human | PGBD4 | 1:2~1:4 | Negative | Online Inquiry |
KO15214 | PGBD4 Knockout cell line (HEK293) | Human | PGBD4 | 1:3~1:6 | Negative | Online Inquiry |
KO15215 | PGBD4 Knockout cell line (A549) | Human | PGBD4 | 1:3~1:4 | Negative | Online Inquiry |
PGBD4 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to lack the PGBD4 gene, a key player within the realm of DNA transposition and genomic integrity. The precise deletion of this gene allows researchers to elucidate its role in various biological processes, including cellular differentiation, gene regulation, and responses to genotoxic stress. By using these knockout cell lines, scientists can systematically study the downstream effects of PGBD4 absence, providing insights into its function and implications in both normal and pathological states.
These cell lines operate through the knockdown of specific gene expression, achieved via techniques such as CRISPR-Cas9 gene editing or homologous recombination. This targeted approach leads to profound changes in cellular behavior, facilitating the identification of novel molecular pathways associated with PGBD4. The implications of studying these interactions are paramount in research settings focused on cancer, neurobiology, and developmental biology, where improper regulation of DNA transposons has been implicated in disease progression.
The scientific importance of PGBD4 Gene Knockout Cell Lines lies in their utility for understanding the fundamental mechanisms of genome stability and gene expression modulation. Clinically, these models may pave the way for the development of therapeutic strategies that address disorders linked to DNA damage and repair pathways.
What distinguishes our PGBD4 Gene Knockout Cell Lines is their enhanced quality control and validation process, which ensures that the genetic modifications are effective, reproducible, and reliable compared to other commercially available models. Additionally, our cell lines come with comprehensive support, including detailed protocols and troubleshooting guidance, making them exceptionally user-friendly for both researchers and clinicians.
In essence, PGBD4 Gene Knockout Cell Lines represent a valuable tool for advancing fundamental biological research and the development of targeted therapies. Our company is dedicated to providing high-quality genetic tools, backed by deep expertise in molecular biology, ensuring that our customers can conduct their research with confidence and precision.
Please note that all services are for research use only. Not intended for any clinical use.
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