Gene: PGBD3
Official Full Name: piggyBac transposable element derived 3provided by HGNC
Gene Summary: This gene is a member of a small family of genes derived from piggyBac transposable elements. The encoded protein contains a zinc-ribbon domain characteristic of transposon-derived proteins and may function as a regulator of transcription. Alternative splicing occurs between a splice site from exon 5 of the adjacent upstream gene 'excision repair cross-complementation group 6' (ERCC6, GeneID: 2074) and the 3' splice site upstream of the open reading frame (ORF) of this gene, which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. Pseudogenes for this gene are defined on chromosomes 4, 5 and 12. [provided by RefSeq, Mar 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20437 | PGBD3 Knockout cell line (HeLa) | Human | PGBD3 | 1:3~1:6 | Negative | Online Inquiry |
KO20438 | PGBD3 Knockout cell line (HCT 116) | Human | PGBD3 | 1:2~1:4 | Negative | Online Inquiry |
KO20439 | PGBD3 Knockout cell line (HEK293) | Human | PGBD3 | 1:3~1:6 | Negative | Online Inquiry |
KO20440 | PGBD3 Knockout cell line (A549) | Human | PGBD3 | 1:3~1:4 | Negative | Online Inquiry |
PGBD3 Gene Knockout Cell Lines are genetically modified cell lines in which the PGBD3 gene has been specifically disrupted, allowing researchers to investigate the functions and pathways associated with this gene's activity. These knockout cell lines serve as essential tools for studying gene function, cellular responses, and the pathways involved in various biological processes. The mechanism behind the knockout involves the use of CRISPR-Cas9 technology, which facilitates precise editing of the genome to achieve targeted gene disruption, leading to a loss of PGBD3 expression.
The scientific importance of PGBD3 Gene Knockout Cell Lines lies in their potential applications in cancer research, developmental biology, and gene therapy studies. By studying the effects of PGBD3 disruption, researchers can uncover its roles in tumorigenesis, differentiation, and cellular stress responses. Furthermore, these cell lines can provide insights into the gene’s contribution to drug resistance mechanisms, enabling the development of more effective therapeutic strategies.
A significant advantage of PGBD3 Gene Knockout Cell Lines over traditional methods, such as the use of RNA interference, is the permanent gene disruption achieved through precise genome editing, which offers a more stable model for ongoing research. This stability leads to more reproducible experimental results, increasing confidence in data obtained from these systems.
Researchers and clinicians seeking reliable and advanced tools to elucidate complex biological questions will find immense value in these knockout cell lines. They enable a deeper understanding of genetic underpinnings in disease states and support the development of novel therapeutic approaches.
Our company specializes in producing high-quality, reliable biological products and tools, underscoring our commitment to advancing scientific research. With an experienced team of scientists and state-of-the-art technology, we ensure that our PGBD3 Gene Knockout Cell Lines meet the highest standards, providing the robust foundation necessary for groundbreaking discoveries in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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