Gene: PERP
Official Full Name: p53 apoptosis effector related to PMP22provided by HGNC
Gene Summary: Involved in activation of cysteine-type endopeptidase activity and positive regulation of neutrophil chemotaxis. Predicted to be located in desmosome and plasma membrane. Predicted to be active in cell-cell junction. Implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO15229 | PERP Knockout cell line (HeLa) | Human | PERP | 1:3~1:6 | Negative | Online Inquiry |
KO15230 | PERP Knockout cell line (HCT 116) | Human | PERP | 1:2~1:4 | Negative | Online Inquiry |
KO15231 | PERP Knockout cell line (HEK293) | Human | PERP | 1:3~1:6 | Negative | Online Inquiry |
KO15232 | PERP Knockout cell line (A549) | Human | PERP | 1:3~1:4 | Negative | Online Inquiry |
PERP Gene Knockout Cell Lines are genetically modified cell lines in which the PERP gene, critical for epithelial integrity and apoptosis regulation, has been selectively disrupted. These cell lines serve as invaluable tools for studying the functional role of the PERP protein in various biological processes, particularly in cancer research. By creating a knockout model, researchers can observe the consequences of gene loss on cell behavior, signaling pathways, and tissue responses.
The key mechanism behind these knockout cell lines lies in the CRISPR-Cas9 gene-editing technology, which allows for precise modifications in the genome. Through this method, the PERP gene is targeted and rendered inactive, enabling researchers to assess the resultant phenotypic changes. This powerful technique not only provides insights into the molecular pathways associated with PERP but also facilitates the exploration of therapeutic interventions in cancer treatment and regenerative medicine.
The scientific importance of PERP Gene Knockout Cell Lines extends to their application in both research and clinical settings. Researchers can leverage these models to investigate the role of PERP in tumorigenesis, examine cellular stress responses, and explore its potential as a prognostic biomarker for various cancers. In clinical research, understanding PERP dysfunction can guide the development of targeted therapies, marking a significant step towards personalized medicine.
What sets our PERP Gene Knockout Cell Lines apart from alternatives is their high specificity and efficiency in gene editing, resulting in stable cell lines that provide reproducible data across experiments. The extensive validation of our knockout cell lines ensures researchers can trust their findings, reducing experimental variability.
For researchers and clinicians seeking to elucidate the role of PERP in disease mechanisms, our PERP Gene Knockout Cell Lines offer a compelling solution that enhances both experimental rigor and translational potential. Our company specializes in cutting-edge genetic tools and is committed to providing high-quality products that empower scientific discovery and innovation in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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