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PEBP1 Knockout Cell Lines

Gene: PEBP1

Official Full Name: phosphatidylethanolamine binding protein 1provided by HGNC

Gene Summary: This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03622 PEBP1 Knockout cell line (HeLa) Human PEBP1 1:3~1:6 Negative Online Inquiry
KO03623 PEBP1 Knockout cell line (HCT 116) Human PEBP1 1:2~1:4 Negative Online Inquiry
KO03624 PEBP1 Knockout cell line (HEK293) Human PEBP1 1:3~1:6 Negative Online Inquiry
KO03625 PEBP1 Knockout cell line (A549) Human PEBP1 1:3~1:4 Negative Online Inquiry

Background

PEBP1 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the expression of the Phosphatidylethanolamine-Binding Protein 1 (PEBP1) gene. This product serves as a powerful tool for researchers studying signaling pathways, protein interactions, and the role of PEBP1 in various biological processes, including apoptosis, inflammation, and cancer progression. PEBP1 acts as a multifaceted modulator in cellular signaling by interacting with key proteins and influencing their functions, making its study critical in understanding pathophysiological mechanisms.

The mechanism by which these knockout cell lines operate relies on the targeted deletion of the PEBP1 gene through state-of-the-art CRISPR/Cas9 technology. This precise gene-editing approach allows for the creation of cell lines lacking PEBP1 expression, enabling researchers to explore the resultant phenotypic and functional changes. The ability to analyze the impact of PEBP1 deficiency on cellular functions provides invaluable insights into therapeutic strategies, potential biomarkers, and drug resistance mechanisms in cancer treatment.

Scientifically, these knockout cell lines are of great importance as they facilitate various applications in research settings, such as functional genomics, drug screening, and mechanistic studies of disease states. They serve as indispensable models for experimental drug validation and help elucidate the complex biological roles of PEBP1, thus contributing to advancements in precision medicine.

What distinguishes our PEBP1 Gene Knockout Cell Lines from other genetic models is their high efficiency and reproducibility, coupled with extensive validation for consistent performance across experimental setups. Unlike alternative products that may not guarantee the complete knockout or lack functional characterization, our lines provide a reliable platform, ensuring researchers can focus on their studies without concerns regarding data variability.

Ultimately, investing in our PEBP1 Gene Knockout Cell Lines embodies a commitment to enhanced scientific discovery and innovation. At our company, we specialize in developing high-quality biological reagents and cell line models, backed by extensive research experience and a dedication to supporting the scientific community. Our offerings are designed to empower researchers and clinicians alike, propelling forward our collective understanding of critical biological processes.

Please note that all services are for research use only. Not intended for any clinical use.

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