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PEA15 Knockout Cell Lines

Gene: PEA15

Official Full Name: proliferation and apoptosis adaptor protein 15provided by HGNC

Gene Summary: This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02545 PEA15 Knockout cell line (HeLa) Human PEA15 1:3~1:6 Negative Online Inquiry
KO02546 PEA15 Knockout cell line (HCT 116) Human PEA15 1:2~1:4 Negative Online Inquiry
KO02547 PEA15 Knockout cell line (HEK293) Human PEA15 1:3~1:6 Negative Online Inquiry
KO02548 PEA15 Knockout cell line (A549) Human PEA15 1:3~1:4 Negative Online Inquiry

Background

PEA15 Gene Knockout Cell Lines are specialized cellular models in which the PEA15 gene has been genetically disrupted, providing invaluable tools for studying the physiological and pathological roles of this gene. PEA15 (Phosphoprotein Enriched in Astrocytes 15) is involved in regulating cell survival and apoptosis, as well as influencing the signaling pathways associated with neurodegenerative disorders. By creating a knockout model, researchers can dissect the precise functions of PEA15 and its associated mechanisms at a cellular level.

The primary function of PEA15 in cellular signaling involves acting as a scaffold that interacts with various proteins implicated in signaling pathways, particularly those related to apoptosis and endoplasmic reticulum stress. Through the elucidation of these intricate signaling networks, scientists can gain insight into the molecular underpinnings of diseases such as Alzheimer's and other neurological disorders. Utilizing PEA15 Gene Knockout Cell Lines allows for the observation of phenotypic differences in cellular behavior, giving researchers a clearer picture of how PEA15 dysregulation may contribute to disease progression.

The scientific importance of PEA15 gene knockout cell lines is evident in both research and clinical applications. These models enable extensive in vitro studies for drug discovery, target validation, and biomarker identification, ultimately contributing to the development of novel therapeutic strategies. Unlike conventional cell lines, the specificity of the knockout model provides a more accurate context for understanding the role of PEA15 in various biological processes and disease states.

One of the key advantages of PEA15 Gene Knockout Cell Lines is their unparalleled specificity and reliability in mimicking the knockout phenotype, which can result in more reproducible results compared to knockdown approaches or other alternative models. Researchers benefit from the consistency and rigor that these specialized cell lines provide, ensuring the integrity of their experimental outcomes.

For researchers and clinicians focused on elucidating the role of PEA15 in disease, our expertly developed PEA15 Gene Knockout Cell Lines are an essential component of their toolkit. They offer powerful insights, expand the potential for groundbreaking discoveries, and support the advancement of therapeutic modalities. Our company prides itself on delivering high-quality biological products, backed by rigorous scientific expertise and a commitment to advancing life sciences research.

Please note that all services are for research use only. Not intended for any clinical use.

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