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PCIF1 Knockout Cell Lines

Gene: PCIF1

Official Full Name: phosphorylated CTD interacting factor 1provided by HGNC

Gene Summary: Enables RNA polymerase II C-terminal domain phosphoserine binding activity; S-adenosyl-L-methionine binding activity; and mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity. Involved in mRNA processing; negative regulation of translation; and positive regulation of translation. Located in intercellular bridge; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15296 PCIF1 Knockout cell line (HeLa) Human PCIF1 1:3~1:6 Negative Online Inquiry
KO15297 PCIF1 Knockout cell line (HCT 116) Human PCIF1 1:2~1:4 Negative Online Inquiry
KO15298 PCIF1 Knockout cell line (HEK293) Human PCIF1 1:3~1:6 Negative Online Inquiry
KO15299 PCIF1 Knockout cell line (A549) Human PCIF1 1:3~1:4 Negative Online Inquiry

Background

PCIF1 Gene Knockout Cell Lines represent a state-of-the-art biological research tool designed to facilitate the study of gene function and molecular pathways involved in various biological processes. Specifically, these cell lines have been engineered to contain a targeted deletion of the PCIF1 gene, allowing researchers to elucidate its role in cellular mechanisms such as transcription regulation, mRNA processing, and response to DNA damage.

The primary function of PCIF1 Gene Knockout Cell Lines lies in their ability to provide an in vivo model that simplifies the investigation of the role PCIF1 plays in various physiological and pathological contexts. By knocking out the PCIF1 gene, researchers can observe changes in cellular behavior, gene expression profiles, and metabolic pathways, thus providing insights into how disruptions in this gene may contribute to disease states or developmental anomalies.

In terms of scientific importance, these cell lines are applicable across multiple domains, from oncology and developmental biology to the study of neurodegenerative diseases. Their use can illuminate novel therapeutic targets and help in the validation of biomarkers, ultimately propelling forward human health research.

One significant advantage of our PCIF1 Gene Knockout Cell Lines is their specificity and reliability, boasting precise knockout efficiency compared to conventional methods such as RNA interference or CRISPR/Cas9 technology alone, which may still allow residual expression of the target gene. Furthermore, these cell lines are thoroughly characterized for key cellular properties, ensuring reproducibility and reliability for subsequent experimental validation.

For researchers and clinicians, the ability to access robust, validated knockout models translates directly into facilitating translational research, enabling a clearer path from basic science discoveries to clinical applications. Therefore, investing in our PCIF1 Gene Knockout Cell Lines not only enhances the quality of experimental outcomes but also accelerates the pace of innovation within labs.

Our company prides itself on expertise in developing high-quality biological products that empower researchers worldwide. With a commitment to advancing scientific understanding, we deliver tools that are designed to meet the evolving needs of both academia and industry.

Please note that all services are for research use only. Not intended for any clinical use.

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