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PBLD Knockout Cell Lines

Gene: PBLD

Official Full Name: phenazine biosynthesis like protein domain containingprovided by HGNC

Gene Summary: Enables identical protein binding activity. Involved in maintenance of gastrointestinal epithelium. Acts upstream of or within with a positive effect on negative regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15328 PBLD Knockout cell line (HeLa) Human PBLD 1:3~1:6 Negative Online Inquiry
KO15329 PBLD Knockout cell line (HCT 116) Human PBLD 1:2~1:4 Negative Online Inquiry
KO15330 PBLD Knockout cell line (HEK293) Human PBLD 1:3~1:6 Negative Online Inquiry
KO15331 PBLD Knockout cell line (A549) Human PBLD 1:3~1:4 Negative Online Inquiry

Background

PBLD Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the study of PBLD (Pyridoxal 5'-phosphate-dependent enzyme) function and its role in various biological processes. These cell lines have been meticulously developed through the CRISPR-Cas9 gene-editing technology to precisely disrupt the PBLD gene, thereby creating a setting that mimics pathological conditions and allows researchers to investigate the gene's contribution to cellular metabolism, signaling pathways, and disease states.

The key function of PBLD Gene Knockout Cell Lines lies in their ability to provide a controlled platform to explore the phenotypic consequences of PBLD loss. Through the elimination of PBLD expression, these cell lines enable scientists to observe changes in metabolic flux, enzymatic activity, and cellular responses to external stimuli—insights that are essential for understanding diseases linked to vitamin B6 metabolism and related genetic disorders.

In both research and clinical settings, these cell lines hold significant scientific importance. They serve as vital tools for drug discovery, biomarker identification, and the validation of therapeutic targets, especially in the context of metabolic diseases and cancer. Researchers can assess the impact of potential therapeutics on PBLD-deficient cells, elucidating the pathways involved in disease progression.

What sets PBLD Gene Knockout Cell Lines apart from other cellular models is their high specificity and reliability. Unlike traditional knockout models, which may exhibit off-target effects, our cell lines provide a consistent genetic background, allowing for reproducible results across experiments. This specificity significantly enhances the validity of experimental outcomes, empowering researchers with confidence in their findings.

For researchers, clinicians, and drug developers, PBLD Gene Knockout Cell Lines are invaluable assets for bridging the gap between basic science and clinical application. By leveraging these tools, users can drive innovation in therapeutic development, unravel complex metabolic pathways, and contribute to the advancement of personalized medicine.

Our company specializes in the production of high-quality biological products that support cutting-edge research and clinical initiatives. With a commitment to scientific excellence, we ensure that our offerings meet the rigorous standards required by the scientific community, empowering researchers to challenge the frontiers of knowledge and unlock new therapeutic possibilities.

Please note that all services are for research use only. Not intended for any clinical use.

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