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PAQR3 Knockout Cell Lines

Gene: PAQR3

Official Full Name: progestin and adipoQ receptor family member 3provided by HGNC

Gene Summary: This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21769 PAQR3 Knockout cell line (HeLa) Human PAQR3 1:3~1:6 Negative Online Inquiry
KO21770 PAQR3 Knockout cell line (HCT 116) Human PAQR3 1:2~1:4 Negative Online Inquiry
KO21771 PAQR3 Knockout cell line (A549) Human PAQR3 1:3~1:4 Negative Online Inquiry

Background

PAQR3 Gene Knockout Cell Lines are genetically modified cell lines designed specifically to lack the expression of the PAQR3 gene, which is implicated in several cellular signaling pathways, including those related to cell growth and apoptosis. By creating these knockout models, researchers can thoroughly investigate the gene's function and its role in various biological processes, offering vital insights into the pathophysiology of numerous diseases.

The key function of PAQR3 Gene Knockout Cell Lines lies in their ability to elucidate the consequences of PAQR3 gene disruption. These cell lines allow scientists to observe changes in cellular behavior, metabolic processes, and response to therapeutic drugs, revealing both the mechanistic insights and potential pathways that govern biological systems. The PAQR3 protein is known to interact with G-protein coupled receptors and regulate signaling pathways that influence cell proliferation and survival, making these cell lines indispensable for studying cancer biology, neurodegenerative disorders, and metabolic diseases.

From a scientific perspective, the significance of PAQR3 Gene Knockout Cell Lines is profound, as they provide a reliable model for testing hypotheses regarding gene function and disease mechanisms. In clinical research settings, these models are instrumental in drug discovery and developmental studies, allowing for targeted therapies that can specifically address the dysregulation stemming from PAQR3 activity.

Compared to conventional models, such as wild-type cell lines or knockdown approaches, PAQR3 Gene Knockout Cell Lines offer a more comprehensive and definitive means of studying gene function. Researchers benefit from the complete absence of the PAQR3 gene, minimizing off-target effects and providing a clearer interpretation of experimental outcomes. Additionally, the robustness and reproducibility of these cell lines enhance their credibility in experimental applications.

For researchers and clinicians seeking to deepen their understanding of molecular mechanisms or explore novel therapeutic avenues, PAQR3 Gene Knockout Cell Lines represent a valuable resource that bridges the gap between fundamental biology and practical application. Our company specializes in the development of advanced genetic tools and models that empower the scientific community, facilitating groundbreaking discoveries and innovations in biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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