Gene: PALS2
Official Full Name: protein associated with LIN7 2, MAGUK p55 family memberprovided by HGNC
Gene Summary: Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05080 | PALS2 Knockout cell line (HeLa) | Human | PALS2 | 1:3~1:6 | Negative | Online Inquiry |
KO05081 | PALS2 Knockout cell line (HCT 116) | Human | PALS2 | 1:2~1:4 | Negative | Online Inquiry |
KO05082 | PALS2 Knockout cell line (HEK293) | Human | PALS2 | 1:3~1:6 | Negative | Online Inquiry |
KO05083 | PALS2 Knockout cell line (A549) | Human | PALS2 | 1:3~1:4 | Negative | Online Inquiry |
PALS2 Gene Knockout Cell Lines are advanced cellular models specifically engineered to facilitate the study of the PALS2 gene and its associated pathways. Created through CRISPR/Cas9 gene editing technology, these cell lines allow researchers to investigate the biological role of the PALS2 gene, which is critical for processes such as tight junction assembly and epithelial barrier function. By knocking out this gene, scientists can elucidate its contributions to cellular signaling and the underlying mechanisms of various diseases, including cancer and neurological disorders.
The key mechanism at play in these knockout cell lines involves the targeted disruption of the PALS2 gene, resulting in the modulation of cellular signaling pathways that are crucial for maintaining tissue integrity and function. The PALS2 knockout models provide a robust platform for researchers to observe phenotypic changes, assess cellular behavior, and uncover novel insights into the molecular dynamics of epithelial cells in both health and disease.
The scientific importance of PALS2 Gene Knockout Cell Lines extends to both basic and applied research. In clinical settings, understanding the function of PALS2 could lead to the development of innovative therapeutic strategies for conditions linked to epithelial dysfunction. Moreover, as researchers seek to unravel complex biological networks, these cell lines prove invaluable for high-throughput screening and drug discovery processes.
One of the major advantages of our PALS2 Gene Knockout Cell Lines compared to alternatives is their robust reproducibility and ease of use, which enable deeper insights into gene function without the limitations often associated with transient knockdown techniques. Unlike other cell lines that may exhibit off-target effects, our knockout models offer clean gene disruptions that enhance the reliability of experimental outcomes.
By providing researchers and clinicians with the tools necessary to explore fundamental biological questions, our PALS2 Gene Knockout Cell Lines represent a significant advancement in the field of cellular and molecular biology. Backed by a commitment to innovation and scientific integrity, our company excels in developing cutting-edge biological products designed to empower the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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