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PACSIN2 Knockout Cell Lines

Gene: PACSIN2

Official Full Name: protein kinase C and casein kinase substrate in neurons 2provided by HGNC

Gene Summary: This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06902 PACSIN2 Knockout cell line (HeLa) Human PACSIN2 1:3~1:6 Negative Online Inquiry
KO06903 PACSIN2 Knockout cell line (HCT 116) Human PACSIN2 1:2~1:4 Negative Online Inquiry
KO06904 PACSIN2 Knockout cell line (HEK293) Human PACSIN2 1:3~1:6 Negative Online Inquiry
KO06905 PACSIN2 Knockout cell line (A549) Human PACSIN2 1:3~1:4 Negative Online Inquiry

Background

PACSIN2 Gene Knockout Cell Lines represent a cutting-edge biotechnological advancement designed for the precise study of the PACSIN2 gene, which is crucial in membrane trafficking and cytoskeletal organization. These engineered cell lines have undergone targeted gene disruption, facilitating the loss of PACSIN2 function, which allows researchers to investigate the gene’s role in various cellular processes such as endocytosis, exocytosis, and synaptic vesicle dynamics.

The primary mechanism of PACSIN2 knockout cell lines involves the use of CRISPR-Cas9 gene editing technology, ensuring highly efficient and precise gene disruption. This technology enables researchers to create a controlled environment to study how the absence of PACSIN2 affects cellular behavior, signaling pathways, and overall cell morphology. By employing these knockout models, scientists can gain insights into PACSIN2’s contributions to diseases like neurodegeneration and cancer, leading to potential therapeutic targets.

In the context of scientific importance, PACSIN2 knockout cell lines have significant applications across molecular biology and pharmaceutical research. Their utility spans from fundamental research into cell biology to translational studies aimed at identifying new drug candidates. This makes them invaluable tools for researchers seeking to understand the pathophysiology of diseases associated with PACSIN2 dysfunction.

Compared to standard wild-type cell lines, PACSIN2 knockout cell lines provide a unique avenue to discover gene-specific functions without the confounding effects of normal gene expression. These cell lines offer researchers reproducible and reliable models for experiments, ultimately enhancing the robustness of experimental outcomes. Additionally, they allow for a more efficient screening of potential therapeutic agents, accelerating the drug discovery process.

For researchers and clinicians dedicated to elucidating cellular mechanisms and developing novel treatments, the PACSIN2 Gene Knockout Cell Lines are indispensable. Their targeted nature enables deepened understanding and innovation in biomedicine. Our company, renowned for its expertise in advanced gene editing technologies and a commitment to product quality, offers these cell lines as part of a comprehensive suite of tools designed to empower scientific discovery and clinical advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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