Gene: P4HTM
Official Full Name: prolyl 4-hydroxylase, transmembraneprovided by HGNC
Gene Summary: The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO21557 | P4HTM Knockout cell line (HeLa) | Human | P4HTM | 1:3~1:6 | Negative | Online Inquiry |
KO21558 | P4HTM Knockout cell line (HCT 116) | Human | P4HTM | 1:2~1:4 | Negative | Online Inquiry |
KO21559 | P4HTM Knockout cell line (HEK293) | Human | P4HTM | 1:3~1:6 | Negative | Online Inquiry |
KO21560 | P4HTM Knockout cell line (A549) | Human | P4HTM | 1:3~1:4 | Negative | Online Inquiry |
P4H™ Gene Knockout Cell Lines represent a cutting-edge innovation in the field of genetic research, designed specifically for investigating gene function and validating gene-targeted therapies. These cell lines have been meticulously developed through the CRISPR/Cas9 genome editing technology, which allows for precise deletion or modification of specific genes. This groundbreaking ability enables researchers to create homologous recombination and evaluate the resultant phenotypic changes, facilitating insights into gene interactions and cellular pathways.
The key functionality of P4H™ Gene Knockout Cell Lines lies in their high specificity and efficiency for gene editing. By knocking out target genes, researchers can observe the biological consequences of gene loss, which aids in elucidating the roles of these genes in various cellular processes such as proliferation, differentiation, and response to therapeutic agents. This precision makes them an indispensable tool in both basic research and translational studies.
Scientifically, these knockout cell lines have significant implications in diverse fields, including oncology, immunology, and regenerative medicine. They provide a robust platform for drug discovery, biomarker identification, and the development of novel therapies. Additionally, their use in preclinical models accelerates the translation of findings to clinical applications.
One of the primary advantages of P4H™ Gene Knockout Cell Lines is their reliability and reproducibility. Unlike traditional methods of gene knockout, which can result in off-target effects and variability, our CRISPR-based approach ensures that gene deletions are both precise and consistent. Particularly in comparison to RNA interference technologies, these cell lines offer stable gene editing, allowing for prolonged studies without the complicating factors associated with transient expression methods.
For researchers and clinicians seeking to deepen their understanding of gene function or expedite the development of gene-targeted therapies, P4H™ Gene Knockout Cell Lines provide an efficient and effective solution. Our commitment to quality and innovation highlights our expertise in delivering superior genetic tools for advancing scientific research and therapeutic development. Embrace the future of genetic exploration with confidence in our P4H™ product line, where precision meets scientific advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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