Gene: OSMR
Official Full Name: oncostatin M receptorprovided by HGNC
Gene Summary: This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00530 | OSMR gRNA3-gRNA4 KO plasmid | OSMR | $850 | |||
GP00581 | OSMR gRNA1-gRNA2 KO plasmid | OSMR | $850 | |||
KO11221 | OSMR Knockout cell line (HeLa) | Human | OSMR | 1:3~1:6 | Negative | Online Inquiry |
KO11222 | OSMR Knockout cell line (HCT 116) | Human | OSMR | 1:2~1:4 | Negative | Online Inquiry |
KO11223 | OSMR Knockout cell line (HEK293) | Human | OSMR | 1:3~1:6 | Negative | Online Inquiry |
KO11224 | OSMR Knockout cell line (A549) | Human | OSMR | 1:3~1:4 | Negative | Online Inquiry |
OSMR Gene Knockout Cell Lines are genetically modified cell lines designed to specifically target and disrupt the OSMR gene, which encodes the oncostatin M receptor. This receptor is integral in various biological processes, including hematopoiesis, inflammation, and neuronal development, by mediating signaling pathways that influence cell proliferation and differentiation. The knockout of the OSMR gene allows researchers to study the functional consequences of OSMR absence or malfunction and to explore its role in various disease models, including cancer and autoimmune disorders.
The key mechanism behind these cell lines involves the CRISPR-Cas9 gene-editing technology, which facilitates precise manipulation of the genome. By inducing double-strand breaks at the OSMR locus, researchers can effectively disrupt gene expression, leading to a complete knockout. This knockout model provides a valuable tool for dissecting the pathways influenced by OSMR signaling and assessing how its loss affects cellular behavior and interaction with surrounding tissues.
In research and clinical settings, OSMR Gene Knockout Cell Lines are critical for advancing our understanding of OSMR's role in pathologies, potentially leading to the identification of novel therapeutic targets and biomarkers. Their application in drug development and validation of treatment efficacy positions them as essential resources for translational research.
What sets our OSMR Gene Knockout Cell Lines apart from alternative products is their validated performance, ensuring reproducibility and reliability in experimental outcomes. Moreover, they come with robust support and detailed documentation for efficient experimental design, making them user-friendly and ideal for both seasoned researchers and newcomers to gene editing.
These cell lines empower researchers and clinicians to uncover new insights into the biological functions of OSMR, ultimately aiding in the development of innovative therapeutic strategies. Our company specializes in the production of high-quality biological products, offering a portfolio that reflects our commitment to advancing scientific research through cutting-edge technologies.
Please note that all services are for research use only. Not intended for any clinical use.
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