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OSBPL8 Knockout Cell Lines

Gene: OSBPL8

Official Full Name: oxysterol binding protein like 8provided by HGNC

Gene Summary: This gene encodes a member of a family of proteins containing an N-terminal pleckstrin homology domain and a highly conserved C-terminal oxysterol-binding protein-like sterol-binding domain. It binds mutliple lipid-containing molecules, including phosphatidylserine, phosphatidylinositol 4-phosphate (PI4P) and oxysterol, and promotes their exchange between the endoplasmic reticulum and the plasma membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30711 OSBPL8 Knockout cell line (HeLa) Human OSBPL8 1:3~1:6 Negative Online Inquiry
KO30712 OSBPL8 Knockout cell line (HCT 116) Human OSBPL8 1:2~1:4 Negative Online Inquiry
KO30713 OSBPL8 Knockout cell line (HEK293) Human OSBPL8 1:3~1:6 Negative Online Inquiry
KO30714 OSBPL8 Knockout cell line (A549) Human OSBPL8 1:3~1:4 Negative Online Inquiry

Background

OSBPL8 Gene Knockout Cell Lines are genetically engineered cell lines designed to facilitate in-depth study of the OSBPL8 gene, which is implicated in lipid metabolism and cellular signaling mechanisms. These cell lines are pivotal for researchers aiming to elucidate the role of OSBPL8 in various biological contexts, including its impact on disease processes such as obesity, cancer, and neurodegenerative disorders.

The primary function of OSBPL8 Gene Knockout Cell Lines lies in their ability to precisely disrupt the OSBPL8 gene using advanced CRISPR-Cas9 technology. This knockout approach ensures the complete ablation of OSBPL8 gene expression, allowing researchers to conduct functional assays that reveal the biological consequences of its absence. By observing alterations in lipid profiles, signaling pathways, and overall cell behavior, scientists can gain critical insights into the gene's role in cellular homeostasis and disease progression.

In terms of scientific importance, these cell lines represent a significant tool in both research and clinical settings. They offer a unique opportunity to investigate OSBPL8’s functional contributions to lipid metabolism and associated pathological conditions. Moreover, they can be employed in drug discovery processes, helping to identify potential therapeutic targets or strategies that might mitigate disturbances caused by OSBPL8 dysregulation.

Compared to alternative models, OSBPL8 Gene Knockout Cell Lines provide enhanced specificity and reliability. Traditional techniques often rely on pharmacological inhibitors or overexpression systems, which may not adequately replicate the gene's natural absence. In contrast, these knockout lines enable researchers to explore phenotypic changes with greater accuracy, resulting in more reproducible and applicable findings.

For researchers and clinicians seeking to deepen their understanding of lipid biology and related diseases, OSBPL8 Gene Knockout Cell Lines offer a valuable avenue for exploration. Their precision and the wealth of insights they can generate make them an essential addition to the toolkit of any laboratory focused on molecular biology and disease research.

Our company specializes in providing cutting-edge genomic tools and cell line solutions with a commitment to supporting scientific advancement. We ensure rigorous quality standards and expert support to help researchers harness the full potential of our biological products.

Please note that all services are for research use only. Not intended for any clinical use.

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