Gene: OSBPL5
Official Full Name: oxysterol binding protein like 5provided by HGNC
Gene Summary: This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04910 | OSBPL5 Knockout cell line (HeLa) | Human | OSBPL5 | 1:3~1:6 | Negative | Online Inquiry |
KO04911 | OSBPL5 Knockout cell line (HCT 116) | Human | OSBPL5 | 1:2~1:4 | Negative | Online Inquiry |
KO04912 | OSBPL5 Knockout cell line (HEK293) | Human | OSBPL5 | 1:3~1:6 | Negative | Online Inquiry |
KO04913 | OSBPL5 Knockout cell line (A549) | Human | OSBPL5 | 1:3~1:4 | Negative | Online Inquiry |
OSBPL5 Gene Knockout Cell Lines are highly specialized cellular models engineered to study the biological role of the OSBPL5 gene, which encodes for the oxysterol-binding protein-like 5, a crucial component involved in lipid metabolism and cellular signaling. These knockout cell lines are created using precise genetic editing technologies such as CRISPR/Cas9, resulting in the targeted deletion of the OSBPL5 gene, allowing researchers to dissect the gene's function without the influence of its protein product.
The primary function of OSBPL5 includes facilitating cholesterol transport and mediating intracellular signaling pathways, particularly relating to lipid homeostasis. By utilizing these knockout cell lines, researchers can explore how the absence of OSBPL5 affects cellular processes, interactions with metabolic pathways, and the potential implications for diseases associated with cholesterol metabolism, including cardiovascular diseases and neurodegenerative disorders.
In terms of scientific importance, OSBPL5 Gene Knockout Cell Lines are invaluable in both basic and applied research settings. They provide a platform for investigating the molecular mechanisms underlying lipid dysregulation and enable scientists to evaluate potential therapeutic interventions targeting OSBPL5-associated pathways.
One of the key advantages of our OSBPL5 Gene Knockout Cell Lines is their high fidelity and reproducibility. Unlike alternative models, these cell lines come with extensive characterization and validation, ensuring that the knockout is complete and that the cells behave predictably under experimental conditions. Additionally, they are compatible with various assays, including drug testing, gene expression analysis, and protein interaction studies.
Researchers and clinicians will find these cell lines particularly valuable as they navigate the complexities of lipid-related disorders, providing a reliable model for hypothesis testing and drug discovery. By leveraging our expertise in genetic engineering and cellular biology, we deliver not only high-quality biological products but also a commitment to advancing scientific research through reliable tools tailored to meet the urgent needs of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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