Gene: OR8U3
Official Full Name: olfactory receptor family 8 subfamily U member 3provided by HGNC
Gene Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28863 | OR8U3 Knockout cell line (HeLa) | Human | OR8U3 | 1:3~1:6 | Negative | Online Inquiry |
KO28864 | OR8U3 Knockout cell line (HCT 116) | Human | OR8U3 | 1:2~1:4 | Negative | Online Inquiry |
KO28865 | OR8U3 Knockout cell line (A549) | Human | OR8U3 | 1:3~1:4 | Negative | Online Inquiry |
OR8U3 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to investigate the function of the OR8U3 gene, which is implicated in the regulation of olfactory perception and neural signaling pathways. By employing CRISPR-Cas9 technology, these cell lines exhibit a reliable knockout of the OR8U3 gene, enabling researchers to study its biological role and interactions in various mammalian systems.
The primary function of OR8U3 Gene Knockout Cell Lines is to facilitate the exploration of olfactory receptor signaling mechanisms. This is achieved through gene editing that results in the complete disruption of OR8U3 transcription, thereby allowing researchers to analyze downstream effects on neuronal activity, receptor-ligand interactions, and olfactory-specific pathways. This model can be pivotal for understanding conditions linked to dysregulated olfaction or neurodegenerative diseases.
The scientific importance of these cell lines extends into various research fields, such as neurobiology, pharmacology, and genetics, providing valuable insights into sensory biology and potential therapeutic targets. In clinical settings, understanding the role of olfactory receptors has implications for the development of olfactory-activated therapeutics and interventions for smell disorders.
Compared to traditional gene knockout methods, which often involve labor-intensive and time-consuming procedures, OR8U3 Gene Knockout Cell Lines offer a streamlined approach with consistent results, minimizing variability and enhancing reproducibility. The precision of CRISPR-Cas9 editing provides a significant advantage, allowing for the creation of knockout lines in a fraction of the time compared to other genetic manipulation techniques.
The value of OR8U3 Gene Knockout Cell Lines to researchers and clinicians lies in their potential to unravel complex biological mechanisms tied to olfaction and related pathologies, which are often overlooked in broader studies. By using these cell lines, users can enhance their research quality and efficiency, laying the groundwork for novel therapeutic strategies.
Our company prides itself on its expertise in producing high-quality, genetically modified cell lines that empower scientific research. With a commitment to advancing gene editing technologies, we provide researchers with invaluable tools that drive innovation and discovery in biological sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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