Home / OGFR Knockout Cell Lines

OGFR Knockout Cell Lines

Gene: OGFR

Official Full Name: opioid growth factor receptorprovided by HGNC

Gene Summary: The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04940 OGFR Knockout cell line (HeLa) Human OGFR 1:3~1:6 Negative Online Inquiry
KO04941 OGFR Knockout cell line (HCT 116) Human OGFR 1:2~1:4 Negative Online Inquiry
KO04942 OGFR Knockout cell line (HEK293) Human OGFR 1:3~1:6 Negative Online Inquiry
KO04943 OGFR Knockout cell line (A549) Human OGFR 1:3~1:4 Negative Online Inquiry

Background

OGFR Gene Knockout Cell Lines are genetically engineered cell lines that have had the Opioid Growth Factor Receptor (OGFR) gene specifically disrupted or "knocked out." This product allows researchers to study the function and role of the OGFR in cellular processes such as proliferation, differentiation, and signaling pathways crucial to various physiological and pathological conditions. The disruption of the OGFR gene can unlock insights into how this receptor influences cancer growth, chronic pain responses, and neurodegenerative diseases, thus providing a valuable tool for biomedical research.

The key functions of OGFR Gene Knockout Cell Lines lie in their ability to mimic disease states or physiological conditions in a controlled setting. By examining these knockout cell lines, researchers can elucidate the mechanisms through which OGFR mediates its biological effects, particularly in relation to opioid signaling and its impact on cell survival. This understanding can be crucial for drug development and therapeutic interventions targeting the opioid system, contributing to the advancement of treatments for conditions like chronic pain or opioid addiction.

The scientific importance of these cell lines extends to both research and clinical applications. Researchers can utilize them in drug screening, providing insights into potential treatments that might affect OGFR-related pathways, while clinicians can benefit from findings that could inform therapeutic strategies for patients. Furthermore, the unique knock-out model enables scientists to determine the role of OGFR in a myriad of biological contexts, making it an indispensable tool for cutting-edge research.

Compared to traditional cell lines that express the OGFR, OGFR Gene Knockout Cell Lines offer a clear advantage by allowing for the direct investigation of the receptor's specific contributions to cellular functioning. This specificity leads to more accurate interpretations of experimental data and ultimately enhances research outcomes.

For researchers, clinicians, and biotech professionals, our OGFR Gene Knockout Cell Lines represent an invaluable asset for advancing scientific knowledge and developing targeted therapies. Our company prides itself on its expertise in genetic engineering and the biology of receptor systems, ensuring that our products meet the highest standards of scientific rigor and reliability. With a commitment to supporting groundbreaking research, we are dedicated to providing tools that empower the scientific community in their quest to understand and treat complex biological challenges.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.