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NUP50 Knockout Cell Lines

Gene: NUP50

Official Full Name: nucleoporin 50provided by HGNC

Gene Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31555 NUP50 Knockout cell line (HeLa) Human NUP50 1:3~1:6 Negative Online Inquiry
KO31556 NUP50 Knockout cell line (HCT 116) Human NUP50 1:2~1:4 Negative Online Inquiry
KO31557 NUP50 Knockout cell line (HEK293) Human NUP50 1:3~1:6 Negative Online Inquiry
KO31558 NUP50 Knockout cell line (A549) Human NUP50 1:3~1:4 Negative Online Inquiry

Background

NUP50 Gene Knockout Cell Lines are genetically engineered cell lines in which the NUP50 gene has been specifically disrupted or knocked out, enabling researchers to study the function and role of this nuclear pore-associated protein in cellular processes. NUP50 is involved in nucleocytoplasmic transport, a crucial mechanism through which proteins and RNA are shuttled between the nucleus and the cytoplasm. The knockout of this gene allows scientists to elucidate its contributions to processes such as gene expression regulation, cell cycle progression, and stress responses.

The key functionality of NUP50 Gene Knockout Cell Lines lies in their ability to offer insights into cellular compartmentalization and signal transduction pathways. By examining these knockout models, researchers can investigate how the absence of NUP50 affects cellular behavior, potentially revealing insights into various diseases where nucleocytoplasmic transport is disrupted, such as cancer and neurodegenerative disorders.

The scientific importance of these cell lines is particularly evident in pharmaceutical research and fundamental biology, as they provide a powerful tool for gene function studies, drug screenings, and mechanistic investigations. Compared to other genetic manipulation methods, NUP50 Gene Knockout Cell Lines provide a stable system for long-term studies without the variability associated with transient transfection methods.

Furthermore, these knockout models are advantageous due to their specificity and reliability, giving researchers more robust results. For clinicians and researchers alike, understanding the nuances of nucleocytoplasmic transport through the study of these cell lines can pave the way for novel therapeutic strategies targeting transport pathways to mitigate disease symptoms.

At our company, we specialize in high-quality, genetically engineered cell lines tailored for advanced research needs. With a strong commitment to innovation and accuracy, we deliver products that empower the scientific community to drive their research forward with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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