Gene: NUDT5
Official Full Name: nudix hydrolase 5provided by HGNC
Gene Summary: This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03153 | NUDT5 Knockout cell line (HeLa) | Human | NUDT5 | 1:3~1:6 | Negative | Online Inquiry |
KO03154 | NUDT5 Knockout cell line (HCT 116) | Human | NUDT5 | 1:2~1:4 | Negative | Online Inquiry |
KO03155 | NUDT5 Knockout cell line (HEK293) | Human | NUDT5 | 1:3~1:6 | Negative | Online Inquiry |
KO03156 | NUDT5 Knockout cell line (A549) | Human | NUDT5 | 1:3~1:4 | Negative | Online Inquiry |
NUDT5 Gene Knockout Cell Lines are advanced biological tools designed for the targeted study of the NUDT5 gene, known for its role in nucleotide metabolism and cellular stress response. By employing CRISPR-Cas9 technology, these cell lines allow for the precise disruption of the NUDT5 gene, enabling researchers to investigate the functional implications of its knockout in various biological processes. The specific mechanism involves the induction of double-strand breaks at the NUDT5 locus, which leads to the generation of mutant cell lines that exhibit a loss of NUDT5 protein expression, thereby providing insights into its molecular pathways.
The scientific importance of NUDT5 Gene Knockout Cell Lines extends into both fundamental research and clinical applications. They facilitate the exploration of the gene's role in cancer biology, metabolic disorders, and responses to drug development, significantly aiding in the understanding of disease mechanisms. Researchers can utilize these cell lines to investigate how the absence of NUDT5 affects cellular proliferation, apoptosis, and metabolic regulation, offering potential pathways for targeted therapies.
Compared to alternative tools such as siRNA or shRNA approaches, these knockout cell lines provide a more stable and long-term study of gene function. Since NUDT5 Gene Knockout Cell Lines allow for complete gene disruption, they ensure more robust experimental results than transient knockdown methods that can produce inconsistent outcomes. Additionally, researchers benefit from the ease of use and reproducibility of experiments, making these lines an attractive option.
The versatility of these cell lines makes them invaluable for researchers and clinicians seeking to deepen their understanding of nucleotide metabolism and its implications in various diseases. Our company prides itself on providing high-quality, well-characterized biological products to support the scientific community. With our expertise in gene editing technologies, we are committed to empowering research that furthers scientific knowledge and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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