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NUDT14 Knockout Cell Lines

Gene: NUDT14

Official Full Name: nudix hydrolase 14provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. This enzyme contains a Nudix hydrolase domain and is a UDPG pyrophosphatase that hydrolyzes UDPG to produce glucose 1-phosphate and UMP. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21063 NUDT14 Knockout cell line (HeLa) Human NUDT14 1:3~1:6 Negative Online Inquiry
KO21064 NUDT14 Knockout cell line (HCT 116) Human NUDT14 1:2~1:4 Negative Online Inquiry
KO21065 NUDT14 Knockout cell line (HEK293) Human NUDT14 1:3~1:6 Negative Online Inquiry
KO21066 NUDT14 Knockout cell line (A549) Human NUDT14 1:3~1:4 Negative Online Inquiry

Background

NUDT14 Gene Knockout Cell Lines are meticulously engineered cellular models designed to elucidate the functional role of the NUDT14 gene, which encodes a protein involved in nucleotide metabolism and RNA processing. These knockout cell lines have been created using advanced CRISPR/Cas9 technology, enabling precise disruption of the NUDT14 gene, resulting in loss-of-function mutations. This targeted approach facilitates in-depth studies on the gene's contributions to cellular processes such as RNA stability, metabolism, and cellular stress responses.

The key function of these knockout cell lines lies in their ability to serve as a powerful tool for researchers investigating the molecular pathways associated with NUDT14. By enabling the assessment of phenotypic changes, gene expression alterations, and metabolic shifts in response to NUDT14 deficiency, these cell lines provide invaluable insights into its role in various biological contexts, including cancer biology and neurodegenerative diseases.

Scientifically, the NUDT14 Gene Knockout Cell Lines hold significant importance across both research and clinical applications. They are particularly useful for identifying potential therapeutic targets and understanding disease mechanisms, thereby contributing to the development of novel treatment strategies. For translational research, these cell lines can offer a platform for testing the efficacy of drugs aimed at modulating NUDT14-related pathways.

When compared to alternative models, such as wild-type or overexpressing cell lines, our knockout variants deliver a unique vantage point for studying loss-of-function effects, which are often critical in understanding gene-specific contributions to pathology. Furthermore, these lines are already validated under optimized conditions, reducing the time and resources typically required for model establishment.

For researchers and clinicians, the NUDT14 Gene Knockout Cell Lines represent a valuable asset, facilitating the dissection of gene function with high specificity and reproducibility. The ability to pinpoint the consequences of NUDT14 depletion paves the way for groundbreaking discoveries in genetics and therapeutic strategies.

Our company specializes in producing high-quality biological products tailored for comprehensive research applications. With a focus on precision engineering and robust validation, we are committed to providing researchers with the tools necessary for advancing scientific knowledge and improving patient outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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