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NUDT1 Knockout Cell Lines

Gene: NUDT1

Official Full Name: nudix hydrolase 1provided by HGNC

Gene Summary: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36541 NUDT1 Knockout cell line (HeLa) Human NUDT1 1:3~1:6 Negative Online Inquiry
KO36542 NUDT1 Knockout cell line (HCT 116) Human NUDT1 1:2~1:4 Negative Online Inquiry
KO36543 NUDT1 Knockout cell line (HEK293) Human NUDT1 1:3~1:6 Negative Online Inquiry
KO36544 NUDT1 Knockout cell line (A549) Human NUDT1 1:3~1:4 Negative Online Inquiry

Background

NUDT1 Gene Knockout Cell Lines are genetically modified cellular models designed to provide a precise and targeted approach to studying the biochemical and physiological implications of the NUDT1 gene, known for its role in nucleotide metabolism and cellular stress response mechanisms. By employing advanced CRISPR-Cas9 gene editing techniques, these knockout cell lines offer researchers a robust platform to explore the functional consequences of NUDT1 deficiency, which has been implicated in various diseases, including cancer and neurodegenerative disorders.

The primary function of NUDT1 involves hydrolyzing oxidized nucleotide triphosphates, thus ensuring the fidelity of DNA and RNA synthesis. By knocking out the NUDT1 gene, researchers can observe alterations in cell cycle regulation, apoptosis, and genomic stability, shedding light on the gene's impact on cellular metabolism and its potential as a therapeutic target. This investigational capability is invaluable for both fundamental research and translational applications, facilitating the development of targeted therapies that can mitigate the effects of NUDT1 dysfunction in disease states.

Compared to traditional cell models that may lack specificity or may not fully recapitulate human cellular mechanisms, NUDT1 Gene Knockout Cell Lines provide distinctive advantages. They allow for more accurate modeling of disease mechanisms and improved predictability of therapeutic responses. Additionally, these cell lines are readily available, offering a ready-to-use solution for laboratories focusing on genetic studies.

For researchers and clinicians specializing in molecular biology, genetics, or pharmacology, the availability of NUDT1 Gene Knockout Cell Lines presents an invaluable resource. Their unique ability to facilitate deeper understandings of gene functions and disease pathways can accelerate research timelines and enhance the validation of novel treatments. Our company, with its expertise in biogenetic engineering and commitment to providing high-quality research tools, ensures that these knockout cell lines meet rigorous scientific standards, paving the way for groundbreaking discoveries in the biomedical field.

Please note that all services are for research use only. Not intended for any clinical use.

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