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NRP1 Knockout Cell Lines

Gene: NRP1

Official Full Name: neuropilin 1provided by HGNC

Gene Summary: This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00457 NRP1 gRNA1-gRNA2 KO plasmid NRP1 $850
GP00467 NRP1 gRNA3-gRNA4 KO plasmid NRP1 $850
KO00741 NRP1 Knockout cell line (A549) Human NRP1 1:3~1:4 Negative Online Inquiry
KO15625 NRP1 Knockout cell line (HeLa) Human NRP1 1:3~1:6 Negative Online Inquiry
KO15626 NRP1 Knockout cell line (HCT 116) Human NRP1 1:2~1:4 Negative Online Inquiry
KO15627 NRP1 Knockout cell line (HEK293) Human NRP1 1:3~1:6 Negative Online Inquiry

Background

NRP1 Gene Knockout Cell Lines are genetically engineered cellular models designed to facilitate the investigation of the neuropilin-1 (NRP1) gene's functions and its associated signaling pathways. NRP1 is a multifunctional co-receptor involved in vascular development, neuronal guidance, and immune responses, making these cell lines invaluable for studying its role in various biological processes and diseases.

The key function of NRP1 Gene Knockout Cell Lines involves the complete deletion of the NRP1 gene, allowing researchers to elucidate the cellular and molecular mechanisms that depend on NRP1 signaling. By observing the physiological and biochemical changes in these knockout cells compared to their wild-type counterparts, researchers can gain insights into how disruptions in NRP1 function may contribute to pathologies such as cancer, cardiovascular diseases, and neurodegenerative disorders.

In research and clinical settings, the application of these cell lines extends to drug discovery, where they serve as models to screen for novel therapeutics that may target NRP1 pathways. Furthermore, they are pivotal in understanding tumor microenvironment interactions and immune evasion mechanisms, providing an essential tool for the development of immune-based therapies.

What sets NRP1 Gene Knockout Cell Lines apart from alternatives is their specificity and precision. Conventional methods of gene silencing, such as RNA interference, may not completely eliminate gene expression, whereas our knockout cell lines ensure total loss of NRP1 function. This specificity results in more robust and reliable experimental outcomes, crucial for downstream analyses.

For researchers and clinicians, utilizing NRP1 Gene Knockout Cell Lines represents a strategic advantage in unraveling complex biological systems and disease mechanisms. The ability to clearly delineate the role of NRP1 opens avenues for innovative research discoveries and potential therapeutic interventions.

Our company brings together a deep expertise in genetic engineering and a commitment to providing high-quality biological products. With rigorous quality control and validation standards, we deliver cell lines that empower your research and enhance your clinical applications, ultimately advancing the frontiers of biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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