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NR2C1 Knockout Cell Lines

Gene: NR2C1

Official Full Name: nuclear receptor subfamily 2 group C member 1provided by HGNC

Gene Summary: This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34938 NR2C1 Knockout cell line (HeLa) Human NR2C1 1:3~1:6 Negative Online Inquiry
KO34939 NR2C1 Knockout cell line (HCT 116) Human NR2C1 1:2~1:4 Negative Online Inquiry
KO34940 NR2C1 Knockout cell line (HEK293) Human NR2C1 1:3~1:6 Negative Online Inquiry
KO34941 NR2C1 Knockout cell line (A549) Human NR2C1 1:3~1:4 Negative Online Inquiry

Background

NR2C1 Gene Knockout Cell Lines are expertly developed cellular models that have undergone targeted gene editing to disrupt the NR2C1 gene, which encodes the nuclear receptor subfamily 2 group C member 1, a key transcription factor involved in various biological processes, including cellular differentiation and metabolism. These knockout cell lines serve as invaluable tools for investigating the functional implications of NR2C1 dysregulation in cellular environments, systematically elucidating the role of this receptor in disease mechanisms, particularly in metabolic disorders and cancers.

The primary function of NR2C1 Gene Knockout Cell Lines lies in their ability to allow researchers to assess the phenotypic and molecular consequences of NR2C1 loss of function. By employing techniques such as CRISPR-Cas9-mediated gene editing, these cell lines provide a stable platform for observing cellular responses in gene expression, signaling pathways, and metabolic alterations. Researchers can use these models to perform high-throughput screening, drug discovery, and mechanistic studies related to NR2C1 activity, significantly advancing the understanding of its role in health and disease.

The scientific importance of NR2C1 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, they enable the dissection of the roles played by NR2C1 in gene regulatory networks, while in clinical research, these models can facilitate the discovery of novel therapeutic targets in diseases linked to NR2C1 dysfunction. Consequently, they are indispensable in advancing personalized medicine approaches and developing targeted therapies.

What sets our NR2C1 Gene Knockout Cell Lines apart from other models is their meticulous validation, ensuring that the knockout is robust and reproducible. Their ease of use in various experimental setups, coupled with the detailed characterization of cellular responses, provides a competitive edge over alternative gene-modified models.

Researchers and clinicians will find remarkable value in these cell lines, as they not only streamline experimental workflows but also enhance the precision of data obtained in studies aimed at unraveling complex biological pathways. Utilizing our NR2C1 Gene Knockout Cell Lines will undoubtedly contribute to significant advancements in the fields of genomics and therapeutic research.

Our company specializes in providing high-quality biological products and cutting-edge gene editing technologies, underpinned by an experienced team dedicated to fostering innovation and accelerating research breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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