Home / NPR1 Knockout Cell Lines

NPR1 Knockout Cell Lines

Gene: NPR1

Official Full Name: natriuretic peptide receptor 1provided by HGNC

Gene Summary: Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07587 NPR1 Knockout cell line (HeLa) Human NPR1 1:3~1:6 Negative Online Inquiry
KO07588 NPR1 Knockout cell line (HEK293) Human NPR1 1:3~1:6 Negative Online Inquiry
KO07589 NPR1 Knockout cell line (A549) Human NPR1 1:3~1:4 Negative Online Inquiry

Background

NPR1 Gene Knockout Cell Lines are genetically engineered model systems that have undergone precise genomic modification to disrupt the expression of the NPR1 gene. This innovative biotechnology product is invaluable for researchers studying the physiological and pathological roles of NPR1, a gene known to be influential in various signaling pathways, particularly in the regulation of plant immunity and stress responses.

The primary function of these cell lines is to enable scientists to investigate the effects of NPR1 depletion on cellular processes. By eliminating the NPR1 gene, researchers can assess changes in gene expression, metabolic pathways, and cellular responses that are mediated by NPR1. This includes an exploration of defense mechanisms against biotic and abiotic stress, as well as insights into the potential interplay between NPR1 and other signaling molecules. The knockout system allows for precise experimental control, further enabling elucidation of NPR1’s role in multifactorial biological contexts.

The scientific importance of NPR1 Gene Knockout Cell Lines extends to both fundamental research and applied clinical settings. In plant biology, these models facilitate improved understanding of disease resistance mechanisms, potentially informing agricultural practices and crop improvement strategies. In biomedical research, insights gained from studying NPR1 knockout may contribute to advancements in understanding related human diseases, such as immune system dysfunctions.

Compared to alternative models, NPR1 Gene Knockout Cell Lines offer a unique and reliable tool for in-depth studies, as they present a clean genetic background devoid of confounding variables associated with partial knockdown techniques. Moreover, these cell lines are ready-to-use, saving researchers valuable time and resources in developing their own knockout models.

This product is particularly valuable for researchers and clinicians aiming for precise experimental conditions to advance their understanding of gene functions. By utilizing NPR1 Gene Knockout Cell Lines, users gain access to a powerful resource that enhances experimental reproducibility and data accuracy.

Our commitment to excellence is reflected in our rigorous production standards and continuous innovation in genetic engineering solutions. We are dedicated to providing researchers with the high-quality tools necessary for advancing scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.